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Authors: Williamson C Depression is one of the most prevalent mental health conditions and can affect people of all ages, but it is becoming more common among the older population with increasing life expectancy. Observational studies have found poor micronutrient status (particularly folate and vitamin B12) to be associated with an increased risk of depression in older people. Supplementation with folic acid has been shown to enhance anti-depressant drug treatment and there is preliminary evidence that supplementation with certain micronutrients may help improve depressive symptoms in older patients. There has also been a lot of interest in the role of long-chain omega-3 fatty acids in depression. However, the evidence from randomized controlled trials is limited and difficult to eval…

Dr. Gold is an attending pediatric gastroenterologist at Children’s Healthcare of Atlanta and a member of the Children’s Center for Digestive Healthcare. He is also a former professor of pediatrics and microbiology, and former director of the division of pediatric gastroenterology, hepatology, and nutrition, at Emory University in Atlanta. Dr. Gold previously was a consultant for AstraZeneca, maker of Losec (omeprazole) and Nexium (esomaprazole), and Takeda Pharmaceuticals, maker of Prevacid (lansoprazole). To respond to this column, e-mail Dr. Gold at pdnews@elsevier.com. (Source: Pediatric News)

EMS is called to the house of a 12-year-old male patient in severe respiratory distress. He has a history of asthma and is on multiple controller medicines, including Flovent, Singulair and albuterol sulfate. On arrival to the house, you find the patient seated in a tripod position. He’s tachypneic and in severe distress. His mother states he developed cold symptoms yesterday and has used his albuterol inhaler multiple times today without improvement. (Source: JEMS: Journal of Emergency Medical Services)

(Source: The British Journal of Psychiatry)

(Source: Reactions)

This study assessed the potential pharmacokinetic interaction and safety/tolerability of taranabant and phentermine coadministration. This was a randomized, double-blind, 3-panel, fixed-sequence study in healthy participants. Panels A, B, and C evaluated the safety/tolerability of phentermine 15 mg coadministered with taranabant 0.5, 1, and 2 mg for 7 days (panel A) and 28 days (panels B and C). In panels A and C, phentermine 15 mg was administered both with (7 days, panel A; 28 days, panel C) and without (7 days) taranabant 0.5 mg or 2 mg to evaluate pharmacokinetics. The primary endpoint was phentermine AUC(0-24 h) in panels A and C. Secondary endpoints were changes from baseline in blood pressure and heart rate for all panels. The geometric mean ratios and 90% confidence intervals for p…

Source: PharmaTimes
Area: News According to a report by Pharmatimes, the European Union panel has approved the use of the antipsychotic SeroquelT and Seroquel XRT (quetiapine) for the prevention of the recurrence of bipolar disorder in patients whose manic, mixed or depressive episode has responded to treatment with the drugs.   Both drugs are the only agents approved in the EU to treat all phases of bipolar disorder. (Source: NeLM – News)

A significant upgrade to our drug interactions information has been completed. Now you can view information on drug interactions, food/ lifestyle (eg: alcohol, caffeine) interactions and disease interactions. This represents a significant amount of newly added information for many thousands of medications. Regular visitors will also notice a complete change in the layout of drug [...]

Cellceutix Corporation today announced it has successfully completed animal model tests on a taxane-resistant, estrogen receptor-negative breast cancer human cell line, MDA-MB-435s, using its proprietary pharmaceutical compound Kevetrin(TM). Tumor volume was reduced by 72% and tumor growth was delayed by more than 52% with Kevetrin when compared with paclitaxel (Taxol) (pIn the experiments, nude mice were implanted subcutaneously with human tumor cells. Groups of 10 mice bearing MDA-MB-435s tumors were treated with Kevetrin, paclitaxel or cisplatin alone or acted as controls. Kevetrin, paclitaxel and cisplatin did no… (Source: Cancercompass News: Breast Cancer)

JERUSALEM–(BUSINESS WIRE)–Sep 25, 2009 – Teva Pharmaceutical
Industries Ltd. (Nasdaq: TEVA) announced today that the U.S. Court
of Appeals for the Federal Circuit has affirmed a July 1, 2008
decision by the District Court to grant AstraZeneca’s… (Source: Drugs.com – Pharma News)