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Treatment with the Spiriva HandiHaler, which contains a dry powder formulation of the anticholinergic tiotropium, does not appear to be associated with an increased risk of stroke, myocardial infarction, or cardiovascular death in patients with chronic obstructive pulmonary disease, the Food and Drug Administration announced. (Source: Family Practice News)

Sun Pharmaceutical Industries’ plan to launch a copy of US-based Wyeth’s blockbuster anti-depressant capsule Effexor XR got a big boost after the US drug regulator rejected rival Osmotica Pharmaceuticals’s appeal to bar the Indian company, said a top executive, reports Khomba Singh. (Source: The Economic Times Healthcare and Biotech News)

Background: The prevalence of drug or alcohol addiction among trauma patients approaches 40%, yet many require narcotics during admission for adequate pain control. Provider awareness is the most reasonable option to avoid the devastating consequence of na… (Source: SafetyLit: All (Unduplicated))

Conclusions:
Taken together, the miR-21 inhibitor could enhance the chemo-sensitivity of human glioblastoma cells to taxol. A combination of miR-21 inhibitor and taxol could be an effective therapeutic strategy for controlling the growth of GBM by inhibiting STAT3 expression and phosphorylation. (Source: BMC Cancer)

CONCLUSION: Postoperative analgesia by iliaca compartment block with catheter seems to provide a decrease in the incidence of POCD after hip surgery in elderly patients. STUDY DESIGN: Prospective, observational study. PMID: 20122812 [PubMed - as supplied by publisher] (Source: Annales Francaises d’Anesthesie et de Reanimation)

RESEARCH TRIANGLE PARK, N.C., Jan. 29 (HSMN NewsFeed) — GlaxoSmithKline (NYSE: GSK) announced today that the U.S. Food and Drug Administration has approved Lamictal (lamotrigine) Extended-Release Tablets as once-a-day, add-on therapy for epilepsy in pat… Biopharmaceuticals, Neurology, FDAGlaxoSmithKline, Lamictal, Lamictal XR, lamotrigine, epilepsy (Source: HSMN NewsFeed)

Proteomics study reveals a protein that, when suppressed,
makes cancers more susceptible to chemotherapy
BOSTON, Jan. 25 /PRNewswire-USNewswire/ — Taxanes, a group of
cancer drugs that includes paclitaxel (Taxol®) and docetaxel
(Taxotere®),… (Source: Drugs.com – Clinical Trials)

Sunitinib is an orally bioavailable small molecule that inhibits multiple receptor tyrosine kinases. Generalized hypersensitivity reactions (HSR) to sunitinib have not been described. A patient with a gastrointestinal stromal tumor (GIST) who developed a type I HSR to sunitinib and who was successfully treated by drug desensitization is reported. A 51-year-old man with metastatic GIST developed a type I HSR during sunitinib treatment. Four days after treatment initiation, the patient presented to the Emergency Department with acute generalized urticaria and facial and throat swelling. Sunitinib was restarted 1 week later, using a desensitization protocol in which 10 escalating reduced doses, beginning with 0.05 mg, were given following pre-medication with prednisone and promethazine. This …

Doctors are worried that as the New Year begins, many Americans will resolve to be thinner in 2010 by using over-the-counter supplements. According to a survey conducted by ADSAM and SenseUS polling companies, about 60 percent of physicians feel troubled about the safety of taking diet pills. Not surprisingly, while physicians feel negatively about the safety of over-the-counter diet pills, they are much more comfortable about the use of injections like Botox and Restylane or even breast implants… (Source: Health News from Medical News Today)

We present evidence for successive engagement of…. (Source: Molecular Cell)