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The Importance of Different Frequency Bands in Predicting Subcutaneous Glucose Concentration in Type 1 Diabetic Patients

drugs — Fri, 30 Jul 2010 08:13:41 +0000

We investigated the relative importance and predictive power of different frequency bands of subcutaneous glucose signals for the short-term (0–50 min) forecasting of glucose concentrations in type 1 diabetic patients with data-driven autoregressive (AR) models. The study data consisted of minute-by-minute glucose signals collected from nine deidentified patients over a five-day period using continuous glucose monitoring devices. AR models were developed using single and pairwise combinations of frequency bands of the glucose signal and compared with a reference model including all bands. The results suggest that: for open-loop applications, there is no need to explicitly represent exogenous inputs, such as meals and insulin intake, in AR models; models based on a single-frequency b…

Popular Diabetes Drugs Associated With Fractures In Type 2 Diabetic Patients

drugs — Fri, 30 Jul 2010 06:16:00 +0000

Postmenopausal women with diabetes taking thiazolidinediones (TZDS), including rosiglitazone and pioglitazone, may be at increased risk for fractures according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). Men with diabetes taking both loop diuretics and TZDs may also be at increased risk of fractures… (Source: Health News from Medical News Today)

Novel Weight-Loss Combo May Lower BP

drugs — Fri, 30 Jul 2010 04:31:05 +0000

Major Finding: In patients on the highest dose of phentermine plus controlled-release topiramate, systolic BP reductions were significantly lower than with placebo: 3.4 mm Hg after 28 weeks in EQUATE, 3.8 mm Hg after 56 weeks in EQUIP, and 3.2 mm Hg after 56 weeks in CONQUER. (Source: Clinical Endocrinology News)

ENDO: Novel Drug Combo May Aid in Weight Loss (CME/CE)

drugs — Fri, 30 Jul 2010 01:12:20 +0000

SAN DIEGO (MedPage Today) — A combination of phentermine and topiramate (Qnexa) appears to induce weight loss and a decrease in metabolic risk parameters for cardiovascular disease in obese patients, researchers reported here. (Source: MedPage Today Endocrinology)

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Unusual Ways to Quit Smoking

drugs — Thu, 29 Jul 2010 20:23:17 +0000

WebMD discusses ways you can kick the smoking habit for good. (Source: WebMD Health)

Just Drop It: The One-Size-Fits-All Approach to Blood Sugar Control, That Is

drugs — Thu, 29 Jul 2010 20:19:17 +0000

July 29, 2010 (EurekAlert) – Aggressive blood sugar control does not improve survival in diabetic patients with kidney failure, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that physicians should individualize blood sugar targets for these patients and not rely on recommendations based on studies in the general population.
read more (Source: Diabetes News from dLife.com)

Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery

drugs — Thu, 29 Jul 2010 20:16:15 +0000

The aim of the present study was to examine the effect of an early stage of streptozotocin-induced diabetes on the mechanism(s) of endothelium-dependent relaxation. Diabetes was induced by a single injection of streptozotocin (48 mg/kg iv), and the ACh-induced relaxation of rat carotid arteries was examined 6 wk later. A diabetes-induced increase in superoxide levels, determined by L-012-induced chemiluminescence, from carotid arteries was associated with endothelial nitric oxide (NO) synthase (eNOS) uncoupling and increased catalytic subunit of NADPH oxidase expression. The sensitivity and maximum response to ACh were similar in normal and diabetic rats despite a decrease in NO release detected by 4-amino-5-methylamino-2′,7′-difluorofluorescein. In normal rats, N-nitro-l-arginine (100 &mi…

Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes

drugs — Thu, 29 Jul 2010 20:03:16 +0000

Cardiac complications and heart failure are the leading cause of death in type 2 diabetic patients. Mitochondrial dysfunction is central in the pathogenesis of the type 2 diabetic heart. However, it is unclear whether this dysfunction is specific for a particular subcellular region. The purpose of this study was to determine whether mitochondrial dysfunction in the type 2 diabetic heart is specific to a spatially distinct subset of mitochondria. We investigated mitochondrial morphology, function, and proteomic composition of subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM) in 18-wk-old db/db mice. Oxidative damage was assessed in subpopulations through the measurement of lipid peroxidation byproducts and nitrotyrosine residues. Proteomic profiles and posttranslationa…

Complex hyperplasia with and without atypia: clinical outcomes and implications of progestin therapy.

drugs — Thu, 29 Jul 2010 19:43:14 +0000

CONCLUSION:: Endometrial carcinoma risk is diminished approximately threefold to fivefold in women diagnosed with complex or atypical endometrial hyperplasia and dispensed progestin; hysterectomy risk is also decreased. LEVEL OF EVIDENCE:: II. PMID: 20664397 [PubMed - in process] (Source: Obstetrics and Gynecology)

Primary iliopsoas abscess and pregnancy.

drugs — Thu, 29 Jul 2010 19:24:42 +0000

CONCLUSION:: Primary iliopsoas abscess should be considered in the differential diagnosis of low-back pain among high-risk pregnant women. Clinicians should be vigilant in identifying high-risk factors and aggressive in treating this rare and potentially fatal complication. PMID: 20664425 [PubMed - in process] (Source: Obstetrics and Gynecology)

Jarisch-herxheimer reaction triggered by group B streptococcus intrapartum antibiotic prophylaxis.

drugs — Thu, 29 Jul 2010 19:22:16 +0000

CONCLUSION:: Beta-lactam antibiotics for group B Streptococcus intrapartum prophylaxis can trigger the Jarisch-Herxhemer reaction in patients with undiagnosed syphilis resulting in unanticipated changes in maternal and fetal well-being. PMID: 20664452 [PubMed - in process] (Source: Obstetrics and Gynecology)

Propylthiouracil-induced agranulocytosis in the third trimester of pregnancy.

drugs — Thu, 29 Jul 2010 19:18:38 +0000

CONCLUSION:: In circumstances in which thionamides are contraindicated, management options of hyperthyroidism in pregnancy are limited. The proximity to term in the third trimester makes expectant management an attractive approach when maternal thyroid indices are stable, allowing for a choice of postpartum therapies without the worry of fetal implications. However, this strategy carries risks, and thyroidectomy in the third trimester can be a safe alternative. PMID: 20664427 [PubMed - in process] (Source: Obstetrics and Gynecology)

Spontaneous Methicillin-Resistant Staphylococcus aureus Epidural Abscess in Pregnancy.

drugs — Thu, 29 Jul 2010 19:14:19 +0000

CONCLUSION:: Spontaneous epidural abscess is a rare condition and diagnosis is often delayed. The finding of Horner syndrome led to imaging of the cervical spine and diagnosis of epidural abscess. Early intervention resulted in resolution of neurologic symptoms and a successful pregnancy outcome. PMID: 20664432 [PubMed - in process] (Source: Obstetrics and Gynecology)

Primary psoas muscle abscess after an uncomplicated spontaneous vaginal delivery.

drugs — Thu, 29 Jul 2010 18:57:46 +0000

CONCLUSION:: Prompt recognition of and subsequent effective treatment for a psoas abscess are crucial to avoid potential long-term morbidity and even mortality. PMID: 20664424 [PubMed - in process] (Source: Obstetrics and Gynecology)

Primary iliopsoas abscess and pregnancy.

drugs — Thu, 29 Jul 2010 18:49:42 +0000

New Health Policy: Encouraging Friendships?

drugs — Thu, 29 Jul 2010 15:47:04 +0000

Having good social relationships – friends, marriage or children – may be every bit as important to a healthy lifespan as quitting smoking, losing weight or taking certain medications, U.S. researchers reported on Tuesday. Reuters Health Information (Source: Medscape Medical News Headlines)

Company Health Plans May Increasingly Demand Proof Family Is Family

drugs — Thu, 29 Jul 2010 11:41:00 +0000

CNNMoney: “Think your whole family is covered by your company health plan? Get ready to prove they’re actually your kin.” Under the new health overhaul law, starting next year “employers will have to provide coverage for dependents of employees [until] age 26. That will further inflate coverage costs for companies at a time when employers are already bracing for a 9% jump in their health care plan expenditures in 2011… (Source: Health News from Medical News Today)

Abbott’s SIMCOR(R) (Niacin Extended-Release / Simvastatin) Receives FDA Approval For New Dosage Strengths

drugs — Thu, 29 Jul 2010 10:03:00 +0000

Abbott received U.S. Food and Drug Administration (FDA) approval for two new dosage strengths of SIMCORÃÂ®, a cholesterol medication. The new SIMCOR dosage strengths combine 40 mg of simvastatin – the most commonly prescribed dose of simvastatin – with either 500 mg or 1,000 mg of niacin extended-release. SIMCOR is the first treatment to combine Abbott’s proprietary niacin extended-release and simvastatin, the most commonly used statin. SIMCOR is a prescription medication used along with diet in people who cannot control their cholesterol levels by diet and exercise alone… (Source: Health News from Medical News Today)

e-Cigarette Aerosol Decreases Over Time In Smoke-Out Interval, Requiring Stronger Puffs

drugs — Thu, 29 Jul 2010 09:44:00 +0000

Stronger suction is required to smoke “electronic cigarettes” – marketed as tobacco-free nicotine delivery systems – than conventional brands, with possible adverse effects on human health, researchers at the University of California, Riverside report. The researchers used a smoking machine to compare the smoking properties of eight conventional cigarettes with five e-cigarette brands. They examined the vacuum required to produce smoke (in the case of conventional cigarettes) or aerosol (in the case of e-cigarettes), and compared the density of the smoke/aerosol over time… (Source: Health News from Medical News Today)

Abbott’s SIMCOR ÃÂ® ( Niacin Extended-release / Simvastatin ) Receives FDA Approval For New Dosage Strengths

drugs — Thu, 29 Jul 2010 08:58:00 +0000

Abbott (NYSE: ABT) received U.S. Food and Drug Administration (FDA) approval for two new dosage strengths of SIMCORÃÂ®, a cholesterol medication. The new SIMCOR dosage strengths combine 40 mg of simvastatin the most commonly prescribed dose of simvastatin with either 500 mg or 1,000 mg of niacin extended-release. SIMCOR is the first treatment to combine Abbott’s proprietary niacin extended-release and simvastatin, the most commonly used statin… (Source: Health News from Medical News Today)

Global Breakthrough In Treatment Of Dementia ‘Within Reach’ – Clinical Trial In Scotland Recruiting

drugs — Thu, 29 Jul 2010 07:52:00 +0000

A Glasgow-based medical research company is leading a worldwide sleep study which could radically reduce the symptoms associated with dementia. The groundbreaking trial, conducted by CPS Research, is the first of its kind to investigate the use of sleep hormone melatonin as an add on treatment for dementia. The study is already showing remarkable initial results in volunteers from Scotland. Melatonin is the natural hormone produced at night to prepare the body for sleep and produced throughout the night to maintain sleep… (Source: Health News from Medical News Today)

Drugs Like Viagra Linked to Higher Rates of STDs

drugs — Thu, 29 Jul 2010 07:06:05 +0000

Title: Drugs Like Viagra Linked to Higher Rates of STDsCategory: Health NewsCreated: 7/5/2010 4:10:00 PMLast Editorial Review: 7/6/2010 (Source: MedicineNet Mens Health General)

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Appropriate prescribing critical to manage pain drugs

drugs — Thu, 29 Jul 2010 06:58:42 +0000

Stronger opioids such as morphine, hydromorphone, oxymorphone, methadone, levorphanol, fentanyl and oxycodone are generally used for treatment of moderate to severe pain. (Source: Managed Healthcare Executive Magazine Online)

African Leaders Agree on Ways Forward on Maternal and Child Health – 27 July 2010

drugs — Thu, 29 Jul 2010 06:31:49 +0000

KAMPALA, Uganda — The high-level debate which opened in Kampala, Uganda, yesterday on “Promoting Maternal, Infant and Child Health and Development in Africa, ended this evening with an agreement by Africa’s leaders on an action plan to kick-start the effective implementation of existing resolutions and decisions on maternal, infant and child health in the continent. (Source: UNFPA News)

Antigenics Presents Positive, Top Line Data From Phase I Herpes Clinical Trial

drugs — Thu, 29 Jul 2010 06:17:00 +0000

Antigenics (NASDAQ: AGEN) announced positive results with AG-707, an investigational therapeutic vaccine being developed to treat herpes simplex virus-2 (HSV-2), the virus that causes genital herpes, in infected patients. Developed by Antigenics, the vaccine triggers a cellular immune response, stimulating both CD4+ and CD8+ T cells. “I believe these data represent the first finding of their kind in genital herpes treatments-showing a vaccine, AG-707, elicits both CD4+ and CD8+ T-cell responses in humans,” said David Koelle, M.D… (Source: Health News from Medical News Today)

Pharmaceutical drug contamination of waterways threatens life on our planet

drugs — Thu, 29 Jul 2010 06:12:00 +0000

This study was the first national-scale evaluation of pharmaceutical drug contamination in streams, and roughly 80 percent of the streams tested were found to be contaminated as well.In 2008, an AP investigation found that at least 46 million Americans are drinking water contaminated with trace amounts of pharmaceuticals. Even though every city tested has its water treated and “purified” prior to being delivered to the public, trace amounts of pharmaceutical drugs are making their way through to the tap. (Since not all major metropolitan areas were tested, the number of people affected is likely far higher than what was reported by AP.)In spite of all this, water quality reports don’t disclose the levels of pharmaceuticals found in tap water. Since the EPA and FDA have failed to establish …

Regional Wetlands Action Plan for the Pacific Islands

drugs — Thu, 29 Jul 2010 05:53:15 +0000

Funding Opportunity Number: RAMSAR2010-2 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: EnvironmentCFDA Number: 15.640Eligible Applicants Others (see text field entitled “Additional Information on Eligibility” for clarification)Agency Name DOI-FWS (Source: Grants.gov)

Effect of centchroman coadministration on the pharmacokinetics of metformin in rats

drugs — Thu, 29 Jul 2010 05:34:48 +0000

Conclusions : The results indicate that centchroman coadministration increases the rate but not the extent of absorption of metformin in rats. However, it does not seem to alter the pharmacokinetics of metformin to clinically significant levels. (Source: Indian Journal of Pharmacology)

Prevalence of multidrug-resistant organisms recovered at a military burn center

drugs — Thu, 29 Jul 2010 05:05:44 +0000

Abstract: Infections caused by multidrug-resistant (MDR) pathogens are associated with significant morbidity and mortality in patients with burn injuries. We performed a 6-year antibiotic susceptibility records review from January 2003 to December 2008 to assess the prevalence of MDR isolates by pathogen at the US Army Institute of Surgical Research Burn Center. During the study period Acinetobacter baumannii (780 isolates [22%]) was the most prevalent organism recovered, followed by Pseudomonas aeruginosa (703 isolates [20%]), Klebsiella pneumoniae (695 isolates [20%]), and Staphylococcus aureus (469 isolates [13%]). MDR prevalence rates among these isolates were A. baumannii 53%, methicillin-resistant S. aureus (MRSA) 34%, K. pneumoniae 17% and P. aeruginosa 15%. Two isolates, 1 A. bauma…

Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: An autopsy series

drugs — Thu, 29 Jul 2010 05:00:40 +0000

This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit over 12 years. The review focused on those patients with death attributed to a bacterial or viral cause by autopsy report. Of 3751 admissions, 228 patients died with 97 undergoing autopsy. Death was attributed to bacteria for 27 patients and to virus for 5 patients. Bacterial pathogens associated with mortality included Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. This association with mortality was independent of % total body surface area burn, % full-thickness burn, inhalation injury, and day of death post-burn. Bloodstream infection was the most common cause of bacteria related de…

Mass casualty incidents with multiple burn victims: Rationale for a Swiss burn plan

drugs — Thu, 29 Jul 2010 04:45:38 +0000

Abstract: Introduction: Mass casualty incidents involving victims with severe burns pose difficult and unique problems for both rescue teams and hospitals. This paper presents an analysis of the published reports with the aim of proposing a rational model for burn rescue and hospital referral for Switzerland.Methods: Literature review including systematic searches of PubMed/Medline, reference textbooks and journals as well as landmark articles.Results: Since hospitals have limited surge capacities in the event of burn disasters, a special approach to both prehospital and hospital management of these victims is required. Specialized rescue and care can be adequately met and at all levels of needs by deploying mobile burn teams to the scene. These burn teams can bring needed skills and enhan…

Tobacco Funds Shrink as Obesity Fight Intensifies

drugs — Thu, 29 Jul 2010 04:45:26 +0000

When the Robert Wood Johnson Foundation decided in 1991 to take on Joe Camel, it became the nation’s largest private funding source for fighting smoking. The foundation spent $700 million to help knock the cartoon character out of advertisements, finance research and advocacy for higher cigarette taxes and smoke-free air laws and, ultimately, to aid in reducing the nation’s smoking rate almost by half. Editor’s Note: James Marks, senior vice president and director of the Health Group at RWJF, and Matthew Myers, president of the Campaign for Tobacco-Free Kids, were quoted in this article. (Source: RWJF News Digest – Public Health)

Sanofi Said to Plan a Bid of $70 for Genzyme

drugs — Thu, 29 Jul 2010 04:43:38 +0000

A deal would bolster SanofiÃ¢ÂÂs drug pipeline and significantly increase its presence in biopharmaceuticals. (Source: NYT Health)

Sleeping Disorders Foreshadow Dementia And ParkinsonÃ¢ÂÂs?

drugs — Thu, 29 Jul 2010 04:27:00 +0000

(Ivanhoe Newswire) — Having a sleeping disorder may be warning your body of future dementia or ParkinsonÃ¢ÂÂs. (Source: Medical Headlines From Ivanhoe.com)

Mechanism uncovered behind Salmonella virulence and drug susceptibility

drugs — Thu, 29 Jul 2010 03:56:00 +0000

(University of Washington) Researchers have discovered a novel mechanism in Salmonella that affects is virulence and its susceptibility to antibiotics. The mechanism changes the bacteria’s production of proteins in a previously unheard of manner. It allows Salmonella to selectively change its levels of certain proteins to respond to inhospital conditions. Although the mechanism had not been recognized before, scientists found evidence of a similar mechanism in all five kingdoms of life. The mechanism appears to have been conserved throughout the course of evolution. (Source: EurekAlert! – Medicine and Health)

Abbott’s SIMCOR(R) (niacin extended-release / simvastatin) Receives FDA Approval for New Dosage Strengths

drugs — Thu, 29 Jul 2010 03:41:22 +0000

ABBOTT PARK, Ill., July 28 (HSMN NewsFeed) — Abbott (NYSE:ABT ) today received U.S. Food and Drug Administration (FDA) approval for two new dosage strengths of SIMCOR®, a cholesterol medication. The new SIMCOR dosage strengths combine 40 mg of simv… Biopharmaceuticals, Cardiology, FDAAbbott, SIMCOR, niacin, simvastatin, cholesterol (Source: HSMN NewsFeed)

Federal Panel Endorses Ticagrelor for ACS

drugs — Thu, 29 Jul 2010 03:13:14 +0000

ADELPHI, Md. (MedPage Today) — An FDA advisory panel has voted overwhelmingly to recommend approval of AstraZeneca’s investigational antiplatelet drug ticagrelor (Brilinta), saying it appears more effective than clopidogrel (Plavix) for patients with acute coronary syndrome who will be treated either medically or with PCI. (Source: MedPage Today Public Health)

Middle school students co-author research on enzyme for activating promising disease-fighters

drugs — Thu, 29 Jul 2010 02:05:00 +0000

Two middle school students from Wisconsin joined a team of scientists who are reporting the first glimpse of the innermost structure of a key bacterial enzyme. It helps activate certain antibiotics and anti-cancer agents so that those substances do their job. (Source: ScienceDaily Headlines)

Evaluation of MTHFR677C>T Polymorphism in Prediction and Prognosis of Esophageal Squamous Cell Carcinoma: A Case-Control Study in a Northern Indian Population.

drugs — Thu, 29 Jul 2010 00:38:59 +0000

In conclusion, MTHFR677C>T polymorphism does not seem to have significant role either in susceptibility or survival of ESCC in a northern Indian population. PMID: 20661822 [PubMed - in process] (Source: Nutrition and Cancer)

Carefusion 2200 Inc – Temno – Class 2 Recall

drugs — Thu, 29 Jul 2010 00:35:07 +0000

Temno Coaxial Chiba Fine Needle Aspiration; a coaxial introducer needle (20G x 15 cm) with a Chiba biopsy needle (22G x 20 cm); sterile, for single use only sets, 5 sets per case; CareFusion, McGaw Park, IL 60085 USA, Made in Dominican Republic; REF CCH2220 For use in soft tissue aspiration such as breast, kidney, liver, lung, thyroid, lymph nodes and other various soft tissue masses. It is not intended for use in the bone. (Source: Medical Device Recalls since July 07, 2006)

GST Polymorphisms Interact With Dietary Factors to Modulate Lung Cancer Risk: Study in a High-Incidence Area.

drugs — Thu, 29 Jul 2010 00:33:56 +0000

Authors: Gervasini G, Jose CS, Carrillo JA, Benitez J, Cabanillas A The aim of this study was to explore possible correlations between glutathione S-transferases (GST) polymorphisms, smoking, diet, and lung cancer susceptibility in a rural Spanish region with one of the highest incidence rates of the country. All lung cancer patients living in the area (103) and 247 matched controls were genotyped for the GST mu 1 (GSTM1) null, GST theta 1 (GSTT1) null, and GST pi 1 (GSTP1) Isoleucine (Ile) 105 valine (Val) polymorphisms and interviewed to gather information on smoking and dietary habits. Neither the presence of GST polymorphisms nor their interaction with smoking was independently associated to lung cancer risk. The intake of carotenoid-rich red and yellow vegetables was inversely ass…

Red wine consumption not associated with reduced risk of colorectal cancer.

drugs — Thu, 29 Jul 2010 00:30:18 +0000

Authors: Chao C, Haque R, Caan BJ, Poon KY, Tseng HF, Quinn VP Red wine contains polyphenol antioxidants that inhibit colorectal cancer (CRC) development in animal studies. We investigated the effect of red wine intake on risk of CRC in the California Men’s Health Study (CMHS). CMHS is a prospective, multiethnic cohort of middle-aged men who were members of the Kaiser Permanente (KP) California Health Plans and completed study questionnaires between 2002-2003. Incident CRC were identified from the health plan cancer registries through the end of 2007 (n = 287). To properly account for potential confounding by previous endoscopy screening, we restricted the primary analyses to CMHS men continuously enrolled in KP between 1998-2002 (n = 43,483 and CRC = 176). We used multivariable Cox re…

Protection of p53 Wild Type Cells From Taxol by Genistein in the Combined Treatment of Lung Cancer.

drugs — Thu, 29 Jul 2010 00:17:34 +0000

This study specifies the basic principles to selectively kill p53-deficient cells (H1299, FaDu) by taxol and to protect p53 wild type cells (A549) by the prior administration of structurally related flavonoids (apigenin, genistein, and quercetin). Cytotoxic and cytostatic properties of flavonoids were investigated in vitro by flow cytometry and were compared to known anticancer drugs (cisplatin, doxorubicin, etoposide). It was confirmed that doxorubicin induced growth arrest and protected A549 cells from taxol while simultaneously killing or blocking H1299 and FaDu cancer cells. It was found that doxorubicin could be successfully substituted in this way by the isoflavone genistein used at physiologically relevant concentrations. The other compounds analyzed revealed less selectivity (apige…

Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in kashmir valley and influence of environmental factors.

drugs — Wed, 28 Jul 2010 23:51:02 +0000

In conclusion, GSTP1val/val and CYP2E1c1c2 genotypes/c2 allele increased the risk of ESCC and EADC, respectively, in the Kashmiri population; whereas GSTM3AB genotype imparted lower risk for both ESCC and EADC. PMID: 20661821 [PubMed - in process] (Source: Nutrition and Cancer)

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Flax Seeds Can Help Breast Cancer Patients

drugs — Wed, 28 Jul 2010 22:44:00 +0000

Dear Pharmacist: My sister has breast cancer and is taking tamoxifen. She would like to take flax-seed supplements (or eat the ground-up seeds/oil), but she doesn’t know if it will help or interfere with her treatment. Her doctor said it was fine but… (Source: OrlandoSentinel: Medical Research)

Government of Canada Supports Accessibility for All Canadians

drugs — Wed, 28 Jul 2010 21:45:22 +0000

The Government of Canada Supports Accessibility for All Canadians – Canada’s Economic Action Plan improves access to facilities, activities and services. (Source: Disabled World)

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Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles

drugs — Wed, 28 Jul 2010 20:56:48 +0000

The epithelium of the mammalian gastric body comprises multiple cell types replenished by a single stem cell. The adult conformation of cell lineages occurs well after birth; hence, study of genes regulating stem cell activity is facilitated by inducible systems for gene deletion. However, there is a potential pitfall involving the commonly used inducible Cre recombinase system to delete genes: we report here that induction of Cre using standard doses of tamoxifen led to marked spasmolytic polypeptide-expressing metaplasia of the stomach within days and profound atrophy of the entire epithelium with foci of hyperplasia by 2 wk even in the absence of loxP-flanked alleles. Cre induction caused genotoxicity with TdT-mediated dUTP nick-end labeling (TUNEL)-positive apoptosis (TUNEL-positive ce…

WellCare gets national accreditation

drugs — Wed, 28 Jul 2010 20:05:20 +0000

WellCare Health Plans Inc. was awarded a full health plan accreditation for its HealthEase of Florida and WellCare of Florida subsidiaries. (WCG) (Source: bizjournals.com Health Care:Health Insurance headlines)

Report says adultBasic coverage in Pa. endangered

drugs — Wed, 28 Jul 2010 19:19:48 +0000

Nearly 46,000 Pennsylvanians enrolled in PennsylvaniaÃ¢ÂÂs adultBasic subsidized health insurance plan could lose their coverage next year if an agreement with the state’s Blue Cross and Blue Shield providers is not renewed, according to a report issued Thursday by the Pennsylvania Budget and Policy Center and the Pennsylvania Health Access Network. (Source: bizjournals.com Health Care:Health Insurance headlines)

Novartis Plans Giveaway of New ChildrenÃ¢ÂÂs Medicine

drugs — Wed, 28 Jul 2010 19:10:02 +0000

The Swiss drug giant will give away up to 250,000 bottles of a liquid medicine to woo parents frustrated by the recall of liquid childrenÃ¢ÂÂs Tylenol. (Source: NYT Health)

Monitoring of Therapy in Congenital Adrenal Hyperplasia [Reviews]

drugs — Wed, 28 Jul 2010 18:42:05 +0000

BACKGROUND:
Congenital adrenal hyperplasia is a group of disorders caused by defects in the adrenal steroidogenic pathways. In its most common form, 21-hydroxylase deficiency, patients develop varying degrees of glucocorticoid and mineralocorticoid deficiency as well as androgen excess. Therapy is guided by monitoring clinical parameters as well as adrenal hormone and metabolite concentrations. CONTENT:
We review the evidence for clinical and biochemical parameters used in monitoring therapy for congenital adrenal hyperplasia. We discuss the utility of 24-h urine collections for pregnanetriol and 17-ketosteroids as well as serum measurements of 17-hydroxyprogesterone, androstenedione, and testosterone. In addition, we examine the added value of daily hormonal profiles obtained from saliva…

US Medicare Issues Final Dialysis Payment Rule

drugs — Wed, 28 Jul 2010 17:42:47 +0000

The U.S. Medicare program has listed its final plan for tightening payments for kidney dialysis treatment and proposed a new rule linking payment for services to performance standards. Reuters Health Information (Source: Medscape Business of Medicine Headlines)

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Gates Lays Out Approach to Reducing Financial Impact of AIDS Epidemic

drugs — Wed, 28 Jul 2010 15:08:26 +0000

Bill Gates presented a plan to reduce the AIDS epidemic with more prevention, reduction of treatment costs, improved delivery of care, and more-efficient approaches to vaccine trials. Medscape Medical News (Source: Medscape Today Headlines)

Investigator-initiated trials of targeted oncology agents: why independent research is at risk?

drugs — Wed, 28 Jul 2010 14:43:51 +0000

Conclusions: Investigator-initiated trials have led to the discovery and development of innovative, safe, and effective cancer treatments. To ensure that such research continues, action will be required on the parts of legislative and regulatory bodies, industry, universities, patient advocacy organisations, and preclinical and clinical academic scientists. (Source: Annals of Oncology)

Habituating individuality: the framing of tuberculosis and its material solutions in republican china.

drugs — Wed, 28 Jul 2010 14:33:03 +0000

Authors: Lei SH In their endeavor to solve China’s tuberculosis crisis, public health advocates in the 1930s framed tuberculosis as a disease of the Chinese family. Instead of being considered as a social disease, tuberculosis drew people’s attention to the graphic details of personal health habits and the allegedly pathogenic structure of the Chinese family. Focusing on so-called unhygienic habits and on the selective acceptance, abandonment, or innovation of household utensils (such as the traditional sleeping platform, the individual cup, and the hygienic table), the author traces the process by which tuberculosis contributed to the making of the modern Chinese body by way of habituating individuality. PMID: 20657056 [PubMed - in process] (Source: Bulletin of the History of Medi…

Welshimer proposes plan to manage jail population

drugs — Wed, 28 Jul 2010 14:08:09 +0000

The Sedgwick County Commission on Wednesday discussed a proposal by Commissioner Gwen Welshimer that she says would help control the countyÃ¢ÂÂs jail population while avoiding a property tax increase. Commissioners voted to refer the plan to the Community Justice Coordinating Council for further review. (Source: bizjournals.com Health Care:Health Insurance headlines)

Predictive values of hCG clearance for risk of methotrexate resistance in low-risk gestational trophoblastic neoplasias

drugs — Wed, 28 Jul 2010 13:56:52 +0000

Conclusion: In the second largest cohort of low-risk GTN patients reported to date, choriocarcinoma pathology and CLhCG ≤0.37 l/day were major independent predictive factors for MTX resistance risk. (Source: Annals of Oncology)

Grant will connect Los Angeles County clinics to HIE

drugs — Wed, 28 Jul 2010 13:47:57 +0000

L.A. Care Health Plan has approved $153,000 in funding for the Western Health Information Network (WHIN) to help connect a minimum of 10 Los Angeles County community clinics to an existing health information exchange network. (Source: Healthcare IT News)

National Briefing | West: California: Oakland Votes to Allow Large-Scale Marijuana Farming

drugs — Wed, 28 Jul 2010 13:26:04 +0000

The Oakland City Council voted in favor of a plan to license four factories where marijuana would be grown and packaged for medical use. (Source: NYT)

California’s Anthem Blue Cross Names New President

drugs — Wed, 28 Jul 2010 11:45:00 +0000

Anthem Blue Cross of California has named former Aetna executive Pam Kehaly to head the insurer after its president resigned a week ago, Los Angeles Times reports. “Kehaly will take the helm Aug. 30. Anthem, a unit of Indianapolis-based WellPoint Inc., is California’s largest for-profit health insurance company.” Anthem came under intense scrutiny earlier this year over a planned rate hike of up to 39 percent for many of its individual insurance plan holders… (Source: Health News from Medical News Today)

Alcohol and arthritis link examined

drugs — Wed, 28 Jul 2010 09:54:00 +0000

Conclusion
This study appears to show an association between a higher frequency of alcohol consumption and both reduced risk of developing rheumatoid arthritis and decreased severity of the disease. However, there are limitations to this study (many of which the researchers highlight), which mean that the conclusions should be interpreted cautiously: This study required the patients to recall their own alcohol consumption, meaning the patients and controls may have over- or under-estimated the amount of alcohol they had consumed. The study asked the participants about the frequency of their drinking rather than about how much they typically drank. As we cannot tell what quantities of alcohol were consumed, it is therefore possible that some individuals who drank less frequently might…

Which antiplatelet therapy is best for patients on PPIs? New trial to the rescue

drugs — Wed, 28 Jul 2010 09:37:04 +0000

A Paris-based clinical trial will set out to determine the efficacy of two antiplatelet drugs, prasugrel (Effient, Daiichi-Sankyo/Eli Lilly) or a double dose of clopidogrel (Plavix, Bristol-Myers Squibb/Sanofi Aventis), in coronary artery disease patients who are taking lansoprazole (Prevacid, Takeda), a proton-pump inhibitor. (Source: Cardiovascular Business News)

DIATHERIX Laboratories Launches STD And HSV Test Panel

drugs — Wed, 28 Jul 2010 08:18:00 +0000

DIATHERIX Laboratories, adds a Sexually Transmitted Disease (STD) panel and Herpes Simplex Virus (HSV) panel to its line up of highly sensitive, rapid response diagnostic panels. The HSV panel identifies herpes simplex viruses 1 and 2 and the STD panel identifies 10 sexually transmitted diseases simultaneously, many of which cannot be accurately identified by current testing methods. These STD organisms, if not appropriately treated, can cause diseases such as syphilis, gonorrhoeae, chlamydia, bacterial vaginosis, etc. and may lead to blindness, infertility or complications during pregnancy… (Source: Health News from Medical News Today)

High capacity and excellent cycling stability of branched cobalt oxide nanowires as Li-insertion materials

drugs — Wed, 28 Jul 2010 07:04:25 +0000

Cheng Chao Li, Xiao Ming Yin, Li Bao Chen, Qiu Hong Li, and Tai Hong Wang In this paper, the authors report the high-performance lithium storage properties of branched cobalt oxide nanowires synthesized through a topotactic conversion route. Compared with other nanosized materials, such branched nanostructures not only inherit the advantages of high surface-to-volume rati … [Appl. Phys. Lett. 97, 043501 (2010)] published Tue Jul 27, 2010. (Source: Applied Physics Letters)

Extended Daylight Hours Influence Teens’ Sleeping Patterns

drugs — Wed, 28 Jul 2010 06:53:00 +0000

In the spring, later sunset and extended daylight exposure delay bedtimes in teenagers, according to researchers at Rensselaer Polytechnic Institute’s Lighting Research Center (LRC). “Biologically, this increased exposure to early evening light in the spring delays the onset of nocturnal melatonin, a hormone that indicates to the body when it’s nighttime,” explains Mariana Figueiro, Ph.D., associate professor. “This extended exposure adds to the difficulties teens have falling asleep at a reasonable hour… (Source: Health News from Medical News Today)

Cutaneous Sarcoidosis

drugs — Wed, 28 Jul 2010 06:42:19 +0000

Semin Respir Crit Care Med 2010; 31: 442-451DOI: 10.1055/s-0030-1262212ABSTRACTSarcoidosis is a systemic disease with skin manifestations. Skin manifestations are classified as nonspecific if they are not characterized by granulomatous inflammation and specific if the lesions have granulomas histologically. Erythema nodosum is the most common nonspecific skin manifestation, and it portends a good prognosis. Specific skin lesions have a varied clinical appearance, although often they can be distinguished by their yellow translucent character. Despite the potential variable appearance, there are common clinical presentations. Lupus pernio lesions are nodular violaceous specific skin lesions found predominantly on the face associated with scarring and a poor prognosis. Treatment of cutaneous …

African Leaders Agree on Ways Forward on Maternal and Child Health – 27 July 2010

drugs — Wed, 28 Jul 2010 06:42:14 +0000

Cutaneous Sarcoidosis

drugs — Wed, 28 Jul 2010 06:21:19 +0000

Extended Daylight Hours Influence Teens’ Sleeping Patterns

drugs — Wed, 28 Jul 2010 06:19:00 +0000

Reply

drugs — Wed, 28 Jul 2010 05:52:32 +0000

We appreciate the interest and comments about our article. Drs Tariq and Mitchell state that some literature on Stratus OCT report retinal thinning in diabetics with minimal or no diabetic retinopathy (DR)Ã¢ÂÂin contrast to our article, which reported no thinning compared with controls. Drs Tariq and Mitchell also ask whether such discrepancy between studies may be accounted for by correcting for the effects of race, age, and sex on retinal thickness (as we did in our study). This is an excellent point and, in our opinion, a very important consideration when designing or interpreting studies with OCT-based outcomes. (Source: American Journal of Ophthalmology)

Depression and Incident Diabetic Foot Ulcers: A Prospective Cohort Study

drugs — Wed, 28 Jul 2010 05:51:39 +0000

Conclusion: Major depression by Patient Health Questionnaire-9 is associated with a 2-fold higher risk of incident diabetic foot ulcers. Future studies of this association should include better measures of peripheral neuropathy and peripheral arterial disease, which are possible confounders or mediators. (Source: The American Journal of Medicine)

Macular Thickness in Diabetic Subjects Without Retinopathy

drugs — Wed, 28 Jul 2010 05:41:31 +0000

The recent report by Kashani and associates analyzing retinal thickness by race, gender, and age adds to the growing literature on optical coherence tomography measured retinal parameters in different populations. Kashani and associates reported Stratus OCT measurements of macular parameters in white, black, and Hispanic individuals of both sexes, including those with diabetes but without retinopathy. They reported no significant differences in the macular parameters of individuals with diabetes without retinopathy compared with controls, using data adjusted for race, gender, and age group. They also reported that mean foveal thickness and foveal center point thickness were statistically greater in males than in females. Black persons had a significantly thinner mean foveal thickness and c…

Indomethacin Activates Peroxisome Proliferator-activated Receptor ÃÂ³ to Improve Insulin Resistance in Cotton Pellet Granuloma Model

drugs — Wed, 28 Jul 2010 05:35:06 +0000

Horm Metab ResDOI: 10.1055/s-0030-1261952AbstractInflammation is involved in the development of insulin resistance and diabetes. However, the effectiveness of anti-inflammatory drugs in diabetic therapy remains obscure. In the present study, the possible mechanisms of indomethacin, one of the nonsteroidal anti-inflammatory drugs, in the improvement of insulin resistance were investigated. Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue. Also, cotton pellet implantation induced impaired glucose utilization and insulin resistance were improved by indomethacin. The decrement in phosphoinsulin receptor and phospho-Akt levels induced by cotton pellet implantation w…

Cytomegalovirus Infection: A Potential Threat to Atrioventricular Conduction?

drugs — Wed, 28 Jul 2010 05:22:40 +0000

In January 2009, a 34-year-old woman with transient high-degree atrioventricular block was referred to the Hippokration Hospital (A). The patient reported effort dyspnea accompanied by asthenia, headaches, myalgias, and diffuse arthralgias, but not syncope. Her medical history was unremarkable, and she did not report smoking, alcohol, or illicit drug abuse and never received blood products. There was no family history of rhythm and conduction disorders. (Source: The American Journal of Medicine)

Office of the Assistant Secretary for Planning and Evaluation; Request for Comments on the Departmental FY 2010-2015 Strategic Plan

drugs — Wed, 28 Jul 2010 05:15:00 +0000

The Department of Health and Human Services (HHS) is seeking public comment on its draft Strategic Plan for fiscal years 2010-2015. (Source: Federal Register updates via the Rural Assistance Center)

Prevalence and Characteristics of Tinnitus among US Adults

drugs — Wed, 28 Jul 2010 05:10:38 +0000

Conclusions: The prevalence of frequent tinnitus is highest among older adults, non-Hispanic whites, former smokers, and adults with hypertension, hearing impairment, loud noise exposure, or generalized anxiety disorder. Prospective studies of risk factors for tinnitus are needed. (Source: The American Journal of Medicine)

LISINOPRIL WITH HYDROCHLOROTHIAZIDE (Lisinopril And Hydrochlorothiazide) Tablet [West-Ward Pharmaceutical Corp]

drugs — Wed, 28 Jul 2010 04:53:00 +0000

Updated Date: Jul 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Technological Innovations in Surgical Approach for Thyroid Cancer

drugs — Wed, 28 Jul 2010 04:48:11 +0000

Over the last decade, surgeons have witnessed dramatic changes in surgical practice as a result of the introduction of new technological advancement. Some of these changes include refinement of techniques in thyroid cancer surgery. The development of various endoscopic thyroidectomy techniques, the addition of the da Vinci robot, and the use of operative adjuncts in thyroid surgery, such as intraoperative neuromonitoring and quick intraoperative parathyroid hormone, have made thyroid cancer surgery not only safer and better accepted by patients with thyroid cancer but also offer them more surgical treatment options. (Source: Journal of Oncology)

Director’s Comments: HHS’ Health Literacy National Action Plan

drugs — Wed, 28 Jul 2010 04:42:41 +0000

Listen to the NLM Director’s Comments on HHS’ Health Literacy National Action Plan. The transcript is also available. The U.S. Department of Health and Human Services (HHS) recently announced a national action plan to enhance the country’s health literacy… (Source: What’s New on MedlinePlus)

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National Briefing | West: California: Oakland Votes to Allow Large-Scale Marijuana Farming

drugs — Wed, 28 Jul 2010 03:53:51 +0000

The Oakland City Council voted in favor of a plan to license four factories where marijuana would be grown and packaged for medical use. (Source: NYT Health)

Spring light influences teen sleep

drugs — Wed, 28 Jul 2010 03:43:20 +0000

TROY, N.Y., July 27 (UPI) — Long daylight hours in spring influence the sleeping patterns of teens, researchers at Rensselaer Polytechnic Institute in Troy, N.Y., said. Rensselaer Polytechnic Institute – Troy New York – New York – United States – Troy (Source: Health News – UPI.com)

Middle school students co-author research on enzyme for activating promising disease-fighters

drugs — Wed, 28 Jul 2010 03:27:00 +0000

(American Chemical Society) Grown-ups aren’t the only ones making exciting scientific discoveries these days. Two middle school students from Wisconsin joined a team of scientists who are reporting the first glimpse of the innermost structure of a key bacterial enzyme. It helps activate certain antibiotics and anti-cancer agents so that those substances do their job. Their study appears in ACS’ weekly journal Biochemistry. (Source: EurekAlert! – Medicine and Health)

FDA Panel to Vote on Blood Thinner Ticagrelor

drugs — Wed, 28 Jul 2010 02:59:14 +0000

WASHINGTON (MedPage Today) — FDA reviewers said AstraZeneca’s investigational antiplatelet ticagrelor (Brilinta) appears more effective than clopidogrel (Plavix) for patients with acute coronary syndrome, but expressed concern that the findings didn’t hold up in a U.S. population. (Source: MedPage Today Public Health)

Termination Can Get Results

drugs — Tue, 27 Jul 2010 23:39:00 +0000

According to early results of the July TMA survey on health plan contracts, 29 percent of practices have terminated one or more contracts within the last two years. (Source: Blogged_Arteries)

Antismoking Efforts Lose Ground to Obesity Fight

drugs — Tue, 27 Jul 2010 23:19:54 +0000

As public health priorities shift, anti-tobacco programs are losing out to the campaign against obesity. (Source: NYT Health)

Effects of vigorous late-night exercise on sleep quality and cardiac autonomic activity

drugs — Tue, 27 Jul 2010 22:41:00 +0000

Sleep is the most important period for recovery from daily load. Regular physical activity enhances overall sleep quality, but the effects of acute exercise on sleep are not well defined. In sleep hygiene recommendations, intensive exercising is not suggested within the last 3 h before bed time, but this recommendation has not been adequately tested experimentally. Therefore, the effects of vigorous late-night exercise on sleep were examined by measuring polysomnographic, actigraphic and subjective sleep quality, as well as cardiac autonomic activity. Eleven (seven men, four women) physically fit young adults (VO2max 54 ÃÂ± 8 mLÃÂ·kg[minus]1ÃÂ·min[minus]1, age 26 ÃÂ± 3 years) were monitored in a sleep laboratory twice in a counterbalanced order: (1) after vigorous late-night exercise; and (2) …

Recipe for Longevity: No Smoking, and Lots of Friends

drugs — Tue, 27 Jul 2010 22:33:00 +0000

A large new meta-analysis suggests that a rich social network helps people reduce their risk of death about as much as avoiding cigarettes (Source: TIME.com: Top Science and Health Stories)

Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans.

drugs — Tue, 27 Jul 2010 22:27:35 +0000

We report here the first steps of the development of the innovative CIME cocktail. This cocktail is designed not only for the major cytochrome P450, with caffeine, amodiaquine, tolbutamide, omeprazole, dextromethorphan and midazolam as substrates of CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A, respectively, but also phase II enzymes UGT 1A1/6/9 with acetaminophen, P-gp and OATP1B1 with digoxin and rosuvastatin, and renal function with memantine. An assay combining ultra-performance liquid chromatography using a 1.7 microm particle size column with tandem mass spectrometry (UPLC/MS/MS) was set up for the simultaneous quantification of the 20 substrates and metabolites after extraction from human plasma using solid-phase extraction. The method was validated in the spirit of the FDA gui…

Phase 1 trial of bortezomib plus R-CHOP in previously untreated patients with aggressive non-Hodgkin lymphoma

drugs — Tue, 27 Jul 2010 22:11:00 +0000

Bortezomib has preclinical and clinical in B-cell lymphomas, both alone and in combination with other agents. A phase 1 evaluation was conducted of bortezomib with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with untreated diffuse large B-cell lymphoma (DLBCL) or mantle cell lymphoma (MCL).Twenty patients (16 with DLBCL and 4 with MCL) with a median age of 66 years (range, 29-84 years) were enrolled. Eleven subjects (55%) had an elevated lactate dehydrogenase level, and 10 patients (50%) had International Prognostic Index scores of 3 to 5. Standard R-CHOP was administered on a 21-day cycle for 6 cycles, with 1 of 3 dose levels of bortezomib (0.7 mg/m2 [n = 4 patients], 1.0 mg/m2 [n = 9 patients], or 1.3 mg/m2 [n = 7 patients]) administered…

Proposed FDA Plan on Prescription Drugs Rejected

drugs — Tue, 27 Jul 2010 21:49:34 +0000

A lack of mandated training for physicians has helped sink a U.S. Food and Drug Administration (FDA) proposal intended to curb misuse of prescription drugs. (Source: Alcohol, Tobacco and Other Drugs News)

New health policy: encouraging friendships?

drugs — Tue, 27 Jul 2010 21:11:53 +0000

WASHINGTON (Reuters) – Having good social relationships — friends, marriage or children — may be every bit as important to a healthy lifespan as quitting smoking, losing weight or taking certain medications, U.S. researchers reported on Tuesday. (Source: Reuters: Health)

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Smoking may worsen outcome of pregnancy complication

drugs — Tue, 27 Jul 2010 21:10:25 +0000

NEW YORK (Reuters Health) – A new study suggests that smokers who develop preeclampsia during pregnancy are at particular risk of suffering the complications associated with the disorder — including preterm delivery, low birth weight and stillbirth. (Source: Reuters: Health)

Business health group saving costs

drugs — Tue, 27 Jul 2010 20:44:18 +0000

New data released by the Business Health Care Group shows that the groupÃ¢ÂÂs self-funded member companies saw a four-year aggregate health care cost decrease of 5.4 percent per health plan member when compared with 2005 base-year costs. (Source: bizjournals.com Health Care:Health Insurance headlines)

Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes

drugs — Tue, 27 Jul 2010 20:43:03 +0000

Diabetic nephropathy is the commonest cause of end-stage renal disease. Inordinate kidney growth and glomerular hyperfiltration at the very early stages of diabetes are putative antecedents to this disease. The kidney is the only organ that grows larger with the onset of diabetes mellitus, yet there remains confusion about the mechanism and significance of this growth. Here we show that kidney proximal tubule cells in culture transition to senescence in response to oxidative stress. We further determine the temporal expression of G1 phase cell cycle components in rat kidney cortex at days 4 and 10 of streptozotocin diabetes to evaluate changes in this growth response. In diabetic rats we observe increases in kidney weight-to-body weight ratios correlating with increases in expression of th…

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A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells

drugs — Tue, 27 Jul 2010 20:05:03 +0000

Leydig cells are responsible for the synthesis and secretion of testosterone, processes controlled by luteinizing hormone (LH). Binding of LH to a G protein-coupled receptor in the plasma membrane results in an increase in cAMP and in intracellular Ca2+ concentration ([Ca2+]i). Here we show, using immunofluorescence, that Leydig cells express ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs). Measurements of intracellular calcium changes using the fluorescent calcium-sensitive dye fluo-3 and confocal microscopy show that both types of receptors are involved in a calcium-induced calcium release (CICR) mechanism, which amplifies the initial Ca2+ influx through plasma membrane T-type calcium channels (CaV3). The RyRs and IP3Rs are functional, as judged from both th…

Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes [Letters]

drugs — Tue, 27 Jul 2010 19:06:04 +0000

(Source: JAMA)

Tobacco Funds Dwindle as Obesity Fight Intensifies

drugs — Tue, 27 Jul 2010 18:52:35 +0000

As public health priorities shift, anti-tobacco programs are losing out to the campaign against obesity. (Source: NYT Health)

Extended use of anti-clotting drug helps some bedridden patients

drugs — Tue, 27 Jul 2010 17:53:00 +0000

A treatment plan used to prevent potentially dangerous blood clots in recovering surgical patients can also benefit some patients immobilized by acute medical illness, doctors have found in a multi-institutional study. (Source: ScienceDaily Headlines)

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Good early results for herpes vaccine

drugs — Tue, 27 Jul 2010 17:47:03 +0000

Antigenics says it has achieved positive results in an early stage human trial for a potential herpes vaccine. A vaccine, if approved, would be a blockbuster pharmaceutical product Ã¢ÂÂ 60 million Americans are infected with herpes simplex virus-2, more commonly known as genital herpes. (Source: bizjournals.com Health Care:Health Insurance headlines)

Mesothelioma-Causing Asbestos May be Banned in the United States

drugs — Tue, 27 Jul 2010 16:07:59 +0000

According to a recent report, the Environmental Protection Agency (EPA) has plans to phase out the use of asbestos within the next decade.
Lin Chien-hui, director of the EPA’s Department of Environmental Sanitation and Toxic Substance Management, said the ban on asbestos will be enforced through two stages.
On July 1, 2015, regulations will be in place to make sure asbestos is no longer used as a sealing material in construction projects. On July 1, 2020, asbestos will be banned for all uses in tiles, linings and extruded cement panels.
The plan to ban asbestos in the United States marks a big step towards lowering the risk of developing asbestos-related diseases. One of these conditions is malignant mesothelioma, a rare form of cancer almost exclusively caused by asbestos exposure. …

Online Pharmacy US

The Importance of Different Frequency Bands in Predicting Subcutaneous Glucose Concentration in Type 1 Diabetic Patients

Popular Diabetes Drugs Associated With Fractures In Type 2 Diabetic Patients

Novel Weight-Loss Combo May Lower BP

ENDO: Novel Drug Combo May Aid in Weight Loss (CME/CE)

Unusual Ways to Quit Smoking

Just Drop It: The One-Size-Fits-All Approach to Blood Sugar Control, That Is

Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery

Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes

Complex hyperplasia with and without atypia: clinical outcomes and implications of progestin therapy.

Primary iliopsoas abscess and pregnancy.

Jarisch-herxheimer reaction triggered by group B streptococcus intrapartum antibiotic prophylaxis.

Propylthiouracil-induced agranulocytosis in the third trimester of pregnancy.

Spontaneous Methicillin-Resistant Staphylococcus aureus Epidural Abscess in Pregnancy.

Primary psoas muscle abscess after an uncomplicated spontaneous vaginal delivery.

Primary iliopsoas abscess and pregnancy.

New Health Policy: Encouraging Friendships?

Company Health Plans May Increasingly Demand Proof Family Is Family

Abbott’s SIMCOR(R) (Niacin Extended-Release / Simvastatin) Receives FDA Approval For New Dosage Strengths

e-Cigarette Aerosol Decreases Over Time In Smoke-Out Interval, Requiring Stronger Puffs

Abbott’s SIMCOR ÃÂ® ( Niacin Extended-release / Simvastatin ) Receives FDA Approval For New Dosage Strengths

Global Breakthrough In Treatment Of Dementia ‘Within Reach’ – Clinical Trial In Scotland Recruiting

Drugs Like Viagra Linked to Higher Rates of STDs

Appropriate prescribing critical to manage pain drugs

African Leaders Agree on Ways Forward on Maternal and Child Health – 27 July 2010

Antigenics Presents Positive, Top Line Data From Phase I Herpes Clinical Trial

Pharmaceutical drug contamination of waterways threatens life on our planet

Regional Wetlands Action Plan for the Pacific Islands

Effect of centchroman coadministration on the pharmacokinetics of metformin in rats

Prevalence of multidrug-resistant organisms recovered at a military burn center

Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: An autopsy series

Mass casualty incidents with multiple burn victims: Rationale for a Swiss burn plan

Tobacco Funds Shrink as Obesity Fight Intensifies

Sanofi Said to Plan a Bid of $70 for Genzyme

Sleeping Disorders Foreshadow Dementia And ParkinsonÃ¢ÂÂs?

Mechanism uncovered behind Salmonella virulence and drug susceptibility

Abbott’s SIMCOR(R) (niacin extended-release / simvastatin) Receives FDA Approval for New Dosage Strengths

Federal Panel Endorses Ticagrelor for ACS

Middle school students co-author research on enzyme for activating promising disease-fighters

Evaluation of MTHFR677C>T Polymorphism in Prediction and Prognosis of Esophageal Squamous Cell Carcinoma: A Case-Control Study in a Northern Indian Population.

Carefusion 2200 Inc – Temno – Class 2 Recall

GST Polymorphisms Interact With Dietary Factors to Modulate Lung Cancer Risk: Study in a High-Incidence Area.

Red wine consumption not associated with reduced risk of colorectal cancer.

Protection of p53 Wild Type Cells From Taxol by Genistein in the Combined Treatment of Lung Cancer.

Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in kashmir valley and influence of environmental factors.

Flax Seeds Can Help Breast Cancer Patients

Government of Canada Supports Accessibility for All Canadians

Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles

WellCare gets national accreditation

Report says adultBasic coverage in Pa. endangered

Novartis Plans Giveaway of New ChildrenÃ¢ÂÂs Medicine

Monitoring of Therapy in Congenital Adrenal Hyperplasia [Reviews]

US Medicare Issues Final Dialysis Payment Rule

Gates Lays Out Approach to Reducing Financial Impact of AIDS Epidemic

Investigator-initiated trials of targeted oncology agents: why independent research is at risk?

Habituating individuality: the framing of tuberculosis and its material solutions in republican china.

Welshimer proposes plan to manage jail population

Predictive values of hCG clearance for risk of methotrexate resistance in low-risk gestational trophoblastic neoplasias

Grant will connect Los Angeles County clinics to HIE

National Briefing | West: California: Oakland Votes to Allow Large-Scale Marijuana Farming

California’s Anthem Blue Cross Names New President

Alcohol and arthritis link examined

Which antiplatelet therapy is best for patients on PPIs? New trial to the rescue

DIATHERIX Laboratories Launches STD And HSV Test Panel

High capacity and excellent cycling stability of branched cobalt oxide nanowires as Li-insertion materials

Extended Daylight Hours Influence Teens’ Sleeping Patterns

Cutaneous Sarcoidosis

African Leaders Agree on Ways Forward on Maternal and Child Health – 27 July 2010

Cutaneous Sarcoidosis

Extended Daylight Hours Influence Teens’ Sleeping Patterns

Reply

Depression and Incident Diabetic Foot Ulcers: A Prospective Cohort Study

Macular Thickness in Diabetic Subjects Without Retinopathy

Indomethacin Activates Peroxisome Proliferator-activated Receptor ÃÂ³ to Improve Insulin Resistance in Cotton Pellet Granuloma Model

Cytomegalovirus Infection: A Potential Threat to Atrioventricular Conduction?

Office of the Assistant Secretary for Planning and Evaluation; Request for Comments on the Departmental FY 2010-2015 Strategic Plan

Prevalence and Characteristics of Tinnitus among US Adults

LISINOPRIL WITH HYDROCHLOROTHIAZIDE (Lisinopril And Hydrochlorothiazide) Tablet [West-Ward Pharmaceutical Corp]

Technological Innovations in Surgical Approach for Thyroid Cancer

Director’s Comments: HHS’ Health Literacy National Action Plan

Abbott’s SIMCOR ÃÂ® ( Niacin Extended-release / Simvastatin ) Receives FDA Approval For New Dosage Strengths

Sleeping Disorders Foreshadow Dementia And ParkinsonÃ¢ÂÂs?

Novartis Plans Giveaway of New ChildrenÃ¢ÂÂs Medicine

Indomethacin Activates Peroxisome Proliferator-activated Receptor ÃÂ³ to Improve Insulin Resistance in Cotton Pellet Granuloma Model