Online Pharmacy US » Alprazolam http://medsnetic.com/blog Viagra, Xanax, Cialis, Phentermine, Levitra Sat, 04 Sep 2010 14:36:15 +0000 http://wordpress.org/?v=2.9.2 en hourly 1 Caffeine augments Alprazolam induced cytotoxicity in human cell lines. http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/ http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/#comments Sun, 30 May 2010 13:45:02 +0000 drugs http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/ Authors: Saha B, Mukherjee A, Samanta S, Saha P, Ghosh AK, Santra CR, Karmakar P
Combined effects of alprazolam (Alp), a member of benzodiazepine group of drugs and caffeine on human cell lines, HeLa and THP1 were investigated in this stu dy. Alp mediated cytotoxicity was enhanced while caffeine was present. The cell death was confirmed by observing morphological changes, LDH assay and membrane anisotropic study. Also such combined effects induced elevated level of ROS and depletion of GSH. The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3. Our results indicate that, Alp alon e induces apoptosis in human…

]]> http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/feed/ 0 Erratum to: Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/#comments Sat, 29 May 2010 13:10:11 +0000 drugs http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Ut recht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsE. P. Prinssen, CNS Research, F. Hoffmann-La Roche, Clinical Development Basel SwitzerlandI. Niklson, CNS Research, F. Hoffmann-La Roche, Clinical Development Base l SwitzerlandC. Xia-Chen, Centre for Human Drug Resear…

]]> http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/feed/ 0 Actavis Launches Alprazolam ER Tablets in the U.S. http://medsnetic.com/blog/2010/05/29/actavis-launches-alprazolam-er-tablets-in-the-u-s-6/ http://medsnetic.com/blog/2010/05/29/actavis-launches-alprazolam-er-tablets-in-the-u-s-6/#comments Sat, 29 May 2010 12:37:41 +0000 drugs http://medsnetic.com/blog/2010/05/29/actavis-launches-alprazolam-er-tablets-in-the-u-s-6/ REYKJAVIK, Iceland, Feb. 14 /PRNewswire-FirstCall/ — Actavis Group (ICEX: ACT), the international generic pharmaceuticals company, today announced that it has re ceived approval from the U.S. Food & Drug Administration to market Alprazolam ER tablets. Distribution of the product will commence in coming weeks.

Alprazolam ER tablets, the generic… (Source: Drug Newswire)

]]> http://medsnetic.com/blog/2010/05/29/actavis-launches-alprazolam-er-tablets-in-the-u-s-6/feed/ 0 Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial http://medsnetic.com/blog/2010/05/29/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial-2/ http://medsnetic.com/blog/2010/05/29/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial-2/#comments Sat, 29 May 2010 10:55:15 +0000 drugs http://medsnetic.com/blog/2010/05/29/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial-2/ AbstractThe respiratory eff ects of benzodiazepines have been controversial. This investigation aimed to study the effe cts of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Ventilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after drug intake. Subjects were encouraged to keep their eyes open. Mean ± SD minute ventilation 120 min after alprazolam and placebo was similar (6.21 ± 0.71 vs 6.41 ± 1.12 L/min, P = NS). End-tidal PCO2 and oxygen saturation did also not differ between treatments. However, coefficients…

]]> http://medsnetic.com/blog/2010/05/29/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial-2/feed/ 0 Actavis Launches Alprazolam ER Tablets In The U.S. http://medsnetic.com/blog/2010/05/28/actavis-launches-alprazolam-er-tablets-in-the-u-s-5/ http://medsnetic.com/blog/2010/05/28/actavis-launches-alprazolam-er-tablets-in-the-u-s-5/#comments Fri, 28 May 2010 03:58:36 +0000 drugs http://medsnetic.com/blog/2010/05/28/actavis-launches-alprazolam-er-tablets-in-the-u-s-5/ Actavis Group (ICEX: ACT), the international generic pharmaceuticals company, today a nnounced that it has received approval from the U.S. Food & Drug Administration to market Alprazolam ER tablets. Distribution of the product will commence in coming weeks. Alprazolam ER tablets, the generic equivalent of Pfizer’s Xanax(R) XR tablets, will be available in 0.5 mg, 1 mg, 2 mg, and 3 mg strengths. [click link for full article] (Source: Anxiety News From Medical News Today)

]]> http://medsnetic.com/blog/2010/05/28/actavis-launches-alprazolam-er-tablets-in-the-u-s-5/feed/ 0 Alexza Completes Enrollment In Phase 2a Clinical Trial With AZ-002 (Staccato(R) Alprazolam) In Panic Disorder Patients http://medsnetic.com/blog/2010/05/28/alexza-completes-enrollment-in-phase-2a-clinical-trial-with-az-002-staccator-alprazolam-in-panic-disorder-patients/ http://medsnetic.com/blog/2010/05/28/alexza-completes-enrollment-in-phase-2a-clinical-trial-with-az-002-staccator-alprazolam-in-panic-disorder-patients/#comments Fri, 28 May 2010 01:56:34 +0000 drugs http://medsnetic.com/blog/2010/05/28/alexza-completes-enrollment-in-phase-2a-clinical-trial-with-az-002-staccator-alprazolam-in-panic-disorder-patients/ Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA) announced that it has completed the enrollment in its Phase 2a proof-of-concept clinical trial with AZ-002 (Staccato(R) alprazolam) in patients with panic disorder. AZ-002 is an inhalation product candidate being developed for the acute treatment of panic attacks associated with panic disorder. AZ-002 is being developed through Symphony Allegro, a development collaboration formed between Alexza and S ymphony Capital in 2006. (Source: Psychology / Psychiatry News From Medical News Today)

]]> http://medsnetic.com/blog/2010/05/28/alexza-completes-enrollment-in-phase-2a-clinical-trial-with-az-002-staccator-alprazolam-in-panic-disorder-patients/feed/ 0 In a 30 year old woman, already taking an SSRI and quetiapine, is there any evidence that cyclical use of alprazolam reduces severity of symptoms of premenstrual dysphoric disorder. If so do the benefits on average outweight potential harms? http://medsnetic.com/blog/2010/05/27/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef-2/ http://medsnetic.com/blog/2010/05/27/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef-2/#comments Thu, 27 May 2010 19:43:59 +0000 drugs http://medsnetic.com/blog/2010/05/27/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef-2/ Unfortunately, we cannot answer this question as we found no guidelines or studies examining the cyclical use of alprazolam to treat premenstrual dysphoric disorder in patients concurrently taking quetiapine and a SSRI. This being the case coupl ed with not knowing the SSRI the patient is taking, plus the possibility of drug reactions occurring between SSRIs, an antipsychotic and a benzodiazepine, the NLH Q & A Service would recommend referring this query to Medicines Information. (Source: NLH Question Answering Service)

]]> http://medsnetic.com/blog/2010/05/27/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef-2/feed/ 0 Anxiolytic therapy with alprazolam increases muscle sympathetic activity in patients with panic disorders. http://medsnetic.com/blog/2010/05/27/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders-2/ http://medsnetic.com/blog/2010/05/27/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders-2/#comments Thu, 27 May 2010 04:42:29 +0000 drugs http://medsnetic.com/blog/2010/05/27/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders-2/ This study demonstrates (1) that anxiolytic therapy with alprazolam increases muscle sympathetic nerve activity and heart rate not o nly in patients with panic disorder but also in healthy controls and (2) that a significant difference in sympathetic nervous system activity between patients and controls, at baseline and during the therapy with alprazolam could not be demonstrated.
PMID: 17363337 [PubMed - as supplied by publisher] (Source: Autonomic Neuroscience)

MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising.

]]> http://medsnetic.com/blog/2010/05/27/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders-2/feed/ 0 Topiramate use in alprazolam addiction. http://medsnetic.com/blog/2010/05/26/topiramate-use-in-alprazolam-addiction-2/ http://medsnetic.com/blog/2010/05/26/topiramate-use-in-alprazolam-addiction-2/#comments Wed, 26 May 2010 21:34:10 +0000 drugs http://medsnetic.com/blog/2010/05/26/topiramate-use-in-alprazolam-addiction-2/ Authors: Michopoulos I, Douzenis A, Christodoulou C, Lykouras L
Alprazolam is successful in reducing anxiety but has a high addictive/misuse potential. Topiramate is a novel anticonvulsant which has be en used as a mood stabilizer. Other anticonvulsants, such as carbamazepine and valproate, have been used in alcohol and benzodiazepine withdrawal. Topiramate has recently been used in alcohol, cocaine and opiates withdrawal. There has been also one report of topiramate use in midazolam withdrawal. In our case of a patient with recurrent major depressive disorder, subthreshold anxiety disorder and addiction to alprazo lam, topiramate appears to be efficient and safe in alprazolam withdrawal.
PMID: 17071548 [PubMed - indexed for MEDLINE] (Source: The World Journal of Biological Psychiatr…

]]> http://medsnetic.com/blog/2010/05/26/topiramate-use-in-alprazolam-addiction-2/feed/ 0 Actavis Launches Alprazolam ER Tablets In The U.S. http://medsnetic.com/blog/2010/05/25/actavis-launches-alprazolam-er-tablets-in-the-u-s-4/ http://medsnetic.com/blog/2010/05/25/actavis-launches-alprazolam-er-tablets-in-the-u-s-4/#comments Tue, 25 May 2010 19:03:36 +0000 drugs http://medsnetic.com/blog/2010/05/25/actavis-launches-alprazolam-er-tablets-in-the-u-s-4/ Actavis Group (ICEX: ACT), the international generic pharmaceuticals company, today announced that it has received approval from the U.S. Food & Drug Administration to market Alprazolam ER tablets. Distribution of the product will commence in coming weeks. Alprazolam ER tablets, the generic equivalent of Pfizer’s Xanax(R) XR tablets, will be available in 0. [click link for full article] (Source: Health News fr om Medical News Today)

]]> http://medsnetic.com/blog/2010/05/25/actavis-launches-alprazolam-er-tablets-in-the-u-s-4/feed/ 0 Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers http://medsnetic.com/blog/2010/05/24/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers-2/ http://medsnetic.com/blog/2010/05/24/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers-2/#comments Mon, 24 May 2010 08:13:31 +0000 drugs http://medsnetic.com/blog/2010/05/24/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers-2/ Conclusions??Alprazolam and quinine metabolism is catalyzed by both CYP3 A4 and CYP3A5. The present study showed that different KTZ enantiomers inhibit CYP3A4 and CYP3A5 to different degrees, indicating that structural differences among the enantiomers would be related to their inhibitory potency on these two enzymes.
Content TypeJournal Article

JournalEuropean Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)

MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising.

]]> http://medsnetic.com/blog/2010/05/24/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers-2/feed/ 0 Absence of Food Effect on the Extent of Alprazolam Absorption from an Orally Disintegrating Tablet http://medsnetic.com/blog/2010/05/24/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet-2/ http://medsnetic.com/blog/2010/05/24/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet-2/#comments Mon, 24 May 2010 05:41:35 +0000 drugs http://medsnetic.com/blog/2010/05/24/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet-2/

Conclusion. Coadministration of food was shown to hav e no effect on extent of absorption of immediate-release alprazolam ODT 1.0 mg when compared with drug administration in the fasted condition; however, the rate of drug absorption was decreased. The clinical significance of the difference in rate of alprazolam absorption is unknown but thought to be minimal. (Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy)

]]> http://medsnetic.com/blog/2010/05/24/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet-2/feed/ 0 Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/#comments Sat, 22 May 2010 20:05:08 +0000 drugs http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ Conclusion  Even though fear-potentiated startle may be used to translate preclini cal evidence to human populations, methodological issues
still hamper the application of this model to early screening of putative anxiolytic drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht Univer sity Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Hei…

]]> http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/feed/ 0 Analytical study proving alprazolam degradation to its main impurity triazolaminoquinoleine through Maillard reaction. http://medsnetic.com/blog/2010/05/22/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction-2/ http://medsnetic.com/blog/2010/05/22/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction-2/#comments Sat, 22 May 2010 13:52:05 +0000 drugs http://medsnetic.com/blog/2010/05/22/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction-2/ Authors: Huidobro AL, Barbas C
Triazolaminoquinoleine is rapidly formed in formulations of alprazolam tablets in presence of excipients, and its generation is speeded up with increasing temperature and humidity. The present paper deal s with detailed quantitative and qualitative studies into the nonactive constituents of the formulation in order to determine the excipient (or the mixture) responsible for the degradation. Our studies have demonstrated that reducing carbohydrate excipients play a fundamental role in the generation of triazolaminoquinoleine, wi th lactose as the main one responsible, through a Maillard reaction. In order to demonstrate the validity of the proposed degradation mechanism, p-nitrobenzaldehyde has been employed as a model of reaction of the nucleophylic attack …

]]> http://medsnetic.com/blog/2010/05/22/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction-2/feed/ 0 Alprazolam induced conformational change in hemoglobin. http://medsnetic.com/blog/2010/05/22/alprazolam-induced-conformational-change-in-hemoglobin-2/ http://medsnetic.com/blog/2010/05/22/alprazolam-induced-conformational-change-in-hemoglobin-2/#comments Sat, 22 May 2010 11:19:12 +0000 drugs http://medsnetic.com/blog/2010/05/22/alprazolam-induced-conformational-change-in-hemoglobin-2/ Authors: Maitra S, Saha B, Santra CR, Mukherjee A, Goswami S, Chanda PK, Karmakar P
Alprazolam (ALP) is a widely prescribed sedative and antidepressant benzodiazepine group of drugs. The wide uses of this drug lead us to investigate its possible interaction with hemoglobin (Hb). Spectrophotometric and spectofluorimetric studies showed strong binding of ALP with Hb. Circular dichroic spectra showed that alpha-helical structure of Hb-subunits has been largely changed. On ALP treatment partial pressure of O(2) is increased in the blood indicating release of O(2) from erythrocytes. Further, the b inding of ALP-induced conform ational changes in Hb resulting in larger Hb particle size was demonstrated by dynamic light scattering experiment. Thus, the present study unambiguously raises questio…

]]> http://medsnetic.com/blog/2010/05/22/alprazolam-induced-conformational-change-in-hemoglobin-2/feed/ 0 Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD. http://medsnetic.com/blog/2010/05/22/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd-2/ http://medsnetic.com/blog/2010/05/22/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd-2/#comments Sat, 22 May 2010 04:28:53 +0000 drugs http://medsnetic.com/blog/2010/05/22/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd-2/

Conclusion: A brief course of alprazolam in the immediate aftermath of stress-exposure is associated with less favorable responses to additional stress-exposure later on. Alprazolam was associated with a significant attenuation of the HPA-respons e, suggesting a possible link between initial HPA-axis response disruption and the subsequent unfavorable outcomes.
PMID: 19167197 [PubMed - as supplied by publisher] (Source: European Neuropsychopharmacology)

]]> http://medsnetic.com/blog/2010/05/22/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd-2/feed/ 0 Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg http://medsnetic.com/blog/2010/05/21/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1a%c2%a0mg/ http://medsnetic.com/blog/2010/05/21/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1a%c2%a0mg/#comments Fri, 21 May 2010 22:35:25 +0000 drugs http://medsnetic.com/blog/2010/05/21/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1a%c2%a0mg/ Conclusions??The acute impairing effects of alprazolam XR 1?mg on driving and psychomotor functions were generally less, as compared to its immediate-release equivalent, but still of sufficient magnitude to inc rease the risk of becoming involved in traffic accidents.
Content TypeJournal Article

JournalPsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)

]]> http://medsnetic.com/blog/2010/05/21/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1a%c2%a0mg/feed/ 0 Cognitive style, alprazolam plasma levels, and treatment response in panic disorder http://medsnetic.com/blog/2010/05/21/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder-2/ http://medsnetic.com/blog/2010/05/21/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder-2/#comments Fri, 21 May 2010 14:36:50 +0000 drugs http://medsnetic.com/blog/2010/05/21/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder-2/ This study investigated an anxiety-prone cognitive style (measured by the Anxious Thoughts and Tendencies Questionnaire, AT&T) as a predictor of the acute response to increasing alprazolam plasma levels in panic disorder. Panic disorder patients (n=26) were treated with escalating doses of alprazolam for 4 weeks, then a fixed dose of 1 mg four times a day for 4 weeks. At 0, 1, 2, 3, 4, 6, and 8 weeks, trough alprazolam plasma levels; clinical, self-report, and performance measures; and vital signs were assessed. Panic attack data were from daily diaries. The repeated response measures were analyzed in relation to alprazolam plasma levels usi ng SAS GENMOD, with patients classified as high or low on the baseline AT&T. Panic attac ks, anticipatory anxiety, fear, avoidance, overall agoraphobia,…

]]> http://medsnetic.com/blog/2010/05/21/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder-2/feed/ 0 Alprazolam potentiates the antiaversive effect induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray http://medsnetic.com/blog/2010/05/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray-2/ http://medsnetic.com/blog/2010/05/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray-2/#comments Thu, 20 May 2010 22:18:06 +0000 drugs http://medsnetic.com/blog/2010/05/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray-2/ Conclusions  Alprazolam as antidepressants com pounds facilitates 5-HT1A- and 5-HT2A-receptor-mediated neurotransmission in the DPAG, implicating this effect in the mode of action of different classes of antipanic
drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-008-1134-7Authors
Valquíria Camin de Bortoli, University of São Paulo Department of Pharmacol ogy, School of Medicine 14049-900 Ribeirão Preto São Paulo BrazilRegina Lúcia Nogueira, University Estácio de Sá Laboratory of Comparative Psychology 20260-060 Rio de Janeiro Rio de Janeiro BrazilHélio Zangrossi, University of São Paulo Department of Pharmacology, School of Medicine 14049-900 Ribeirão Preto São Paulo Brazil

Journal PsychopharmacologyOnline ISSN 1432-20…

]]> http://medsnetic.com/blog/2010/05/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray-2/feed/ 0 An evaluation of data for 10 children born to mothers who attempted suicide by taking large doses of alprazolam during pregnancy http://medsnetic.com/blog/2010/05/20/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy-2/ http://medsnetic.com/blog/2010/05/20/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy-2/#comments Thu, 20 May 2010 15:51:05 +0000 drugs http://medsnetic.com/blog/2010/05/20/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy-2/ The objective of this study was to evaluate the effects on fetal development of very large doses of alprazolam that were used for suicide attempts during pregnancy. Pregnant women were identified among the patients of the Department of Toxicology Internal Medicine, Korányi Hospital, Budapest, who were admitted as self-poisoned subjects f rom a total population of the three million people of Budapest and its surrounding region. Rates of congenital abnormalities, intrauterine fetal development, and cognitive-behavioral status were compared between children born to mother s who attempted suicide during pregnancy using alprazolam alone or in combination with other drugs and in their sib controls. Between 1984 and 1993, 559 pregnant women attempted suicide during pregnancy with drugs: 30 o…

]]> http://medsnetic.com/blog/2010/05/20/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy-2/feed/ 0 Med Sci Monit 2009; 15(11):PI55-60 "The effects of alprazolam on tinnitus: A cross-over randomized clinical trial" http://medsnetic.com/blog/2010/05/19/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial-2/ http://medsnetic.com/blog/2010/05/19/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial-2/#comments Wed, 19 May 2010 20:39:19 +0000 drugs http://medsnetic.com/blog/2010/05/19/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial-2/ Conclusions: These results suggest that although alprazolam did not improve the THI score or sensation level of loudness significantly, it has a desirable effect on VAS. Further work is needed to determine the beneficial effects of alprazolam in distressed or depressed patients. (Source: Medical Science Monitor)

]]> http://medsnetic.com/blog/2010/05/19/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial-2/feed/ 0 Comment on the successful treatment by Dueñas-Laita et al of chronic drug-resistant urticaria with alprazolam http://medsnetic.com/blog/2010/05/19/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam-2/ http://medsnetic.com/blog/2010/05/19/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam-2/#comments Wed, 19 May 2010 08:43:03 +0000 drugs http://medsnetic.com/blog/2010/05/19/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam-2/ To the Editor: In their letter, Dueñas-Laita et al show an effect of alprazolam in the treatment of chronic drug-resistant urticaria, which provides a therapeutic measurement for chronic urticaria (CU), especially chronic idiopathic urticaria. However, we have several doubts. (Source: Journal of Allergy and Clinical Immunology)

]]> http://medsnetic.com/blog/2010/05/19/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam-2/feed/ 0 Comment on the successful treatment by Dueñas-Laita et al of chronic drug-resistant urticaria with alprazolam http://medsnetic.com/blog/2010/05/08/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam/ http://medsnetic.com/blog/2010/05/08/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam/#comments Sat, 08 May 2010 12:32:57 +0000 drugs http://medsnetic.com/blog/2010/05/08/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam/ To the Editor: In their letter, Dueñas-Laita et al show an effect of alprazolam in the treatment of chronic drug-resistant urticaria, which provides a therapeutic measurement for chronic urticaria (CU), especially chronic idiopathic urticaria. However, we have several doubts. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative he alth and news sources.

]]> http://medsnetic.com/blog/2010/05/08/comment-on-the-successful-treatment-by-duea%c2%b1as-laita-et-al-of-chronic-drug-resistant-urticaria-with-alprazolam/feed/ 0 Actavis Receives Approval of Alprazolam ODT in the U.S. http://medsnetic.com/blog/2010/05/06/actavis-receives-approval-of-alprazolam-odt-in-the-u-s/ http://medsnetic.com/blog/2010/05/06/actavis-receives-approval-of-alprazolam-odt-in-the-u-s/#comments Thu, 06 May 2010 20:07:58 +0000 drugs http://medsnetic.com/blog/2010/05/06/actavis-receives-approval-of-alprazolam-odt-in-the-u-s/ Actavis Group, the international generic pharmaceuticals company, today announced that it has received approval from the U.S. Food & Drug Administration to market Alprazolam orally disintegrating tablets. Distribution of the product will commence immediately. (Source: Pharmaceutical Online News)

MedWorm Message: Get the v ery latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/05/06/actavis-receives-approval-of-alprazolam-odt-in-the-u-s/feed/ 0 Erratum to: Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/#comments Mon, 26 Apr 2010 13:44:17 +0000 drugs http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social S ciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsE. P. Prinssen, CNS Research, F. Hoffmann-La Roche, Clinical Development Basel SwitzerlandI. Niklson, CNS Research, F. Hoffmann-La Roch e, Clinical Development Basel SwitzerlandC. Xia-Chen, Centre for Human Drug Resear…

]]> http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/feed/ 0 The Effects of Antecedent GABAA Activation with Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Man. http://medsnetic.com/blog/2010/03/18/the-effects-of-antecedent-gabaa-activation-with-alprazolam-on-counterregulatory-responses-to-hypoglycemia-in-healthy-man/ http://medsnetic.com/blog/2010/03/18/the-effects-of-antecedent-gabaa-activation-with-alprazolam-on-counterregulatory-responses-to-hypoglycemia-in-healthy-man/#comments Thu, 18 Mar 2010 17:05:43 +0000 drugs http://medsnetic.com/blog/2010/03/18/the-effects-of-antecedent-gabaa-activation-with-alprazolam-on-counterregulatory-responses-to-hypoglycemia-in-healthy-man/ Conclusion: Alprazolam activation of GABA(A) pathways during day 1 hypoglycemia can play an important role in regulating a spectrum of key physiologic responses during subsequent (day 2) hypoglycemia in healthy man.
PMID: 20086227 [PubMed - as supplied by publisher] (Source: Diabetes)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly fr om thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/03/18/the-effects-of-antecedent-gabaa-activation-with-alprazolam-on-counterregulatory-responses-to-hypoglycemia-in-healthy-man/feed/ 0 Xanax (Alprazolam) – updated on RxList http://medsnetic.com/blog/2010/03/13/xanax-alprazolam-updated-on-rxlist/ http://medsnetic.com/blog/2010/03/13/xanax-alprazolam-updated-on-rxlist/#comments Sat, 13 Mar 2010 10:20:09 +0000 drugs http://medsnetic.com/blog/2010/03/13/xanax-alprazolam-updated-on-rxlist/ Xanax (Alprazolam) drug description – FDA approved labeling for prescription drugs and medications at RxList (Source: RxList – New and Updated Drug Monographs)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/03/13/xanax-alprazolam-updated-on-rxlist/feed/ 0 Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg. – Leufkens TR, Vermeeren A, Smink BE, van Ruitenbeek P, Ramaekers JG. http://medsnetic.com/blog/2010/03/06/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1-mg-leufkens-tr-vermeeren-a-smink-be-van-ruitenbeek-p/ http://medsnetic.com/blog/2010/03/06/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1-mg-leufkens-tr-vermeeren-a-smink-be-van-ruitenbeek-p/#comments Sat, 06 Mar 2010 05:33:38 +0000 drugs http://medsnetic.com/blog/2010/03/06/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1-mg-leufkens-tr-vermeeren-a-smink-be-van-ruitenbeek-p/ RATIONALE: Alprazolam extended-release (XR) is approved for the t reatment of panic disorder. This sustained formulation is absorbed in a delayed manner and is therefore expected to produce fewer and less severe side effects than its immediate release equiv… (Source: SafetyLit: All (Unduplicated))

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/03/06/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1-mg-leufkens-tr-vermeeren-a-smink-be-van-ruitenbeek-p/feed/ 0 Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg http://medsnetic.com/blog/2010/03/03/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1%c2%a0mg/ http://medsnetic.com/blog/2010/03/03/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1%c2%a0mg/#comments Wed, 03 Mar 2010 22:36:45 +0000 drugs http://medsnetic.com/blog/2010/03/03/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1%c2%a0mg/ Conclusions??The acute impairing effects of alprazolam XR 1?mg on driving and psychomotor functions were generally less, as compared to its immediate-release equivalent, but still of sufficient magnitude to increase the risk of becoming involved in traffic accidents.
Content TypeJournal Article

JournalPsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (So urce: Psychopharmacology)

]]> http://medsnetic.com/blog/2010/03/03/cognitive-psychomotor-and-actual-driving-performance-in-healthy-volunteers-after-immediate-and-extended-release-formulations-of-alprazolam-1%c2%a0mg/feed/ 0 Med Sci Monit 2009; 15(11):PI55-60 "The effects of alprazolam on tinnitus: A cross-over randomized clinical trial" http://medsnetic.com/blog/2010/03/03/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial/ http://medsnetic.com/blog/2010/03/03/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial/#comments Wed, 03 Mar 2010 04:51:48 +0000 drugs http://medsnetic.com/blog/2010/03/03/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial/ Conclusions: These results suggest that although alprazolam did not improve the THI score or sensation level of loudness significantly, it has a desirable effect on VAS. Further work is needed to determine the beneficial effects of alprazolam in distressed or depressed patients. (Source: Medical Science Monitor)

]]> http://medsnetic.com/blog/2010/03/03/med-sci-monit-2009-1511pi55-60-the-effects-of-alprazolam-on-tinnitus-a-cross-over-randomized-clinical-trial/feed/ 0 alprazolam, Xanax, Kanax XR, Niravam http://medsnetic.com/blog/2010/03/03/alprazolam-xanax-kanax-xr-niravam/ http://medsnetic.com/blog/2010/03/03/alprazolam-xanax-kanax-xr-niravam/#comments Wed, 03 Mar 2010 04:18:48 +0000 drugs http://medsnetic.com/blog/2010/03/03/alprazolam-xanax-kanax-xr-niravam/ Title: alprazolam, Xanax, Kanax XR, NiravamCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 1/30/2008 (Source: MedicineNet Arthritis General)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/03/03/alprazolam-xanax-kanax-xr-niravam/feed/ 0 Absence of Food Effect on the Extent of Alprazolam Absorption from an Orally Disintegrating Tablet http://medsnetic.com/blog/2010/03/03/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet/ http://medsnetic.com/blog/2010/03/03/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet/#comments Wed, 03 Mar 2010 03:31:07 +0000 drugs http://medsnetic.com/blog/2010/03/03/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet/

Conclusion. Coadministration of foo d was shown to have no effect on extent of absorption of immediate-release alprazolam ODT 1.0 mg when compared with drug administration in the fasted condition; however, the rate of drug absorption was decreased. The clinical significance of the difference in rate of alprazolam absorption is unknown but thought to be minimal. (Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy)

]]> http://medsnetic.com/blog/2010/03/03/absence-of-food-effect-on-the-extent-of-alprazolam-absorption-from-an-orally-disintegrating-tablet/feed/ 0 Anxiolytic therapy with alprazolam increases muscle sympathetic activity in patients with panic disorders. http://medsnetic.com/blog/2010/03/03/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders/ http://medsnetic.com/blog/2010/03/03/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders/#comments Wed, 03 Mar 2010 01:51:34 +0000 drugs http://medsnetic.com/blog/2010/03/03/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders/ This study demonstrates (1) that anxiolytic therapy with alprazolam increases muscle sympathetic nerve activity and heart rate not only in patients with panic disorder but a lso in healthy controls and (2) that a significant difference in sympathetic nervous system activity between patients and controls, at baseline and during the therapy with alprazolam could not be demonstrated.
PMID: 17363337 [PubMed - as supplied by publisher] (Source: Autonomic Neuroscience)

]]> http://medsnetic.com/blog/2010/03/03/anxiolytic-therapy-with-alprazolam-increases-muscle-sympathetic-activity-in-patients-with-panic-disorders/feed/ 0 Actavis Launches Alprazolam ER Tablets in the U.S. http://medsnetic.com/blog/2010/03/02/actavis-launches-alprazolam-er-tablets-in-the-u-s-3/ http://medsnetic.com/blog/2010/03/02/actavis-launches-alprazolam-er-tablets-in-the-u-s-3/#comments Tue, 02 Mar 2010 23:25:09 +0000 drugs http://medsnetic.com/blog/2010/03/02/actavis-launches-alprazolam-er-tablets-in-the-u-s-3/ REYKJAVIK, Iceland, Feb. 14 /PRNewswire-FirstCall/ — Actavis Group (ICEX: ACT), the international generic pharmaceuticals company, today announced that it has recei ved approval from the U.S. Food & Drug Administration to market Alprazolam ER tablets. Distribution of the product will commence in coming weeks.

Alprazolam ER tablets, the generic… (Source: Drug Newswire)

]]> http://medsnetic.com/blog/2010/03/02/actavis-launches-alprazolam-er-tablets-in-the-u-s-3/feed/ 0 Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers http://medsnetic.com/blog/2010/03/01/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers/ http://medsnetic.com/blog/2010/03/01/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers/#comments Mon, 01 Mar 2010 11:47:55 +0000 drugs http://medsnetic.com/blog/2010/03/01/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers/ Conclusions??Alprazolam and quinine metabolism is catalyzed by both CYP3A4 and CYP3A5. The present study showed that different KTZ enantiomers inhibit CYP3A4 and CYP3A5 to different degrees, indicating that structural differences among the enantiomers would be related to their inhibitory potency on these two enzymes.
Content TypeJournal Article

JournalEuropean Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-697 0 (Source: European Journal of Clinical Pharmacology)

]]> http://medsnetic.com/blog/2010/03/01/inhibition-of-cyp3a4-and-cyp3a5-catalyzed-metabolism-of-alprazolam-and-quinine-by-ketoconazole-as-racemate-and-four-different-enantiomers/feed/ 0 Topiramate use in alprazolam addiction. http://medsnetic.com/blog/2010/02/21/topiramate-use-in-alprazolam-addiction/ http://medsnetic.com/blog/2010/02/21/topiramate-use-in-alprazolam-addiction/#comments Sun, 21 Feb 2010 20:25:10 +0000 drugs http://medsnetic.com/blog/2010/02/21/topiramate-use-in-alprazolam-addiction/ Authors: Michopoulos I, Douzenis A, Christodoulou C, Lykouras L
Alprazolam is successful in reducing anxiety but has a high addictive/misuse potential. Topiramate is a novel anticonvulsant which has been used as a mood stabilizer. Other antic onvulsants, such as carbamazepine and valproate, have been used in alcohol and benzodiazepine withdrawal. Topiramate has recently been used in alcohol, cocaine and opiates withdrawal. There has been also one report of topiramate use in midazolam withdrawal. In our case of a patient with recurrent major depressive disorder, subthreshold anxiety disorder and addiction to alprazolam, topiramate appears to be efficient and safe in alprazol am withdrawal.
PMID: 17071548 [PubMed - indexed for MEDLINE] (Source: The World Journal of Biological Psychiatr…

]]> http://medsnetic.com/blog/2010/02/21/topiramate-use-in-alprazolam-addiction/feed/ 0 Alprazolam potentiates the antiaversive effect induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray http://medsnetic.com/blog/2010/02/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray/ http://medsnetic.com/blog/2010/02/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray/#comments Sat, 20 Feb 2010 12:48:53 +0000 drugs http://medsnetic.com/blog/2010/02/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray/ Conclusions  Alprazolam as antidepressants compounds facilitates 5-HT1A- and 5-HT2A-receptor-mediated neurotransmission in the DPAG, implicating this effect in the mode of action of different classes of antipanic
drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-008-1134-7Authors
Valquíria Camin de Bortoli, University of São Paulo Department of Pharmacology, School of Medicine 14049-900 Ribeirão Preto São Paulo BrazilRegina Lúcia Nogueira, University Estácio de Sá Labora tory of Comparative Psychology 20260-060 Rio de Janeiro Rio de Janeiro BrazilHélio Zangrossi, University of São Paulo Department of Pharmacology, School of Medicine 14049-900 Ribeirão Preto São Paulo Brazil

Journal PsychopharmacologyOnline ISSN 1432-20…

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of aut horitative health and news sources.

]]> http://medsnetic.com/blog/2010/02/20/alprazolam-potentiates-the-antiaversive-effect-induced-by-the-activation-of-5-ht1a-and-5-ht2a-receptors-in-the-rat-dorsal-periaqueductal-gray/feed/ 0 Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/#comments Wed, 17 Feb 2010 17:49:05 +0000 drugs http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ Conclusion  Even though fear-potentiated startle may be used to translate preclinical evidence to human populations, methodological issues
still hamper the application of this model to early screening of putative anxiolytic drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht Univ ersity Department of Experimental Psychology, Faculty of Social Scien ces Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Hei…

]]> http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/feed/ 0 Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial http://medsnetic.com/blog/2010/02/17/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial/ http://medsnetic.com/blog/2010/02/17/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial/#comments Wed, 17 Feb 2010 07:06:37 +0000 drugs http://medsnetic.com/blog/2010/02/17/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial/ AbstractThe respiratory effects of benzodiazepines have been controversial. This investigation aimed to study the effects of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Vent ilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after drug intake. Subjects were encouraged to keep their eyes open. Mean ± SD minute ventilation 120 min after alprazolam and placebo was similar (6.21 ± 0.71 vs 6.41 ± 1.12 L/min, P = NS). En d-tidal PCO2 and oxygen saturation did also not differ between treatments. However, coefficients…

]]> http://medsnetic.com/blog/2010/02/17/does-oral-alprazolam-affect-ventilation-a-randomised-double-blind-placebo-controlled-trial/feed/ 0 In a 30 year old woman, already taking an SSRI and quetiapine, is there any evidence that cyclical use of alprazolam reduces severity of symptoms of premenstrual dysphoric disorder. If so do the benefits on average outweight potential harms? http://medsnetic.com/blog/2010/02/17/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef/ http://medsnetic.com/blog/2010/02/17/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef/#comments Wed, 17 Feb 2010 06:38:59 +0000 drugs http://medsnetic.com/blog/2010/02/17/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef/ Unfortunately, we cannot answer this question as we found no guidelines or studies examining the cyclical use of alprazolam to treat premenstrual dysphoric disorde r in patients concurrently taking quetiapine and a SSRI. This being the case coupled with not knowing the SSRI the patient is taking, plus the possibility of drug reactions occurring between SSRIs, an antipsychotic and a benzodiazepine, the NLH Q & A Service would recommend referring this query to Medicines Information. (Source: NLH Question Answering Service)

]]> http://medsnetic.com/blog/2010/02/17/in-a-30-year-old-woman-already-taking-an-ssri-and-quetiapine-is-there-any-evidence-that-cyclical-use-of-alprazolam-reduces-severity-of-symptoms-of-premenstrual-dysphoric-disorder-if-so-do-the-benef/feed/ 0 Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD. http://medsnetic.com/blog/2010/02/17/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd/ http://medsnetic.com/blog/2010/02/17/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd/#comments Wed, 17 Feb 2010 03:29:17 +0000 drugs http://medsnetic.com/blog/2010/02/17/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd/ Conclusion: A brief course of alprazolam in the immediate aftermath of stress-exposure is associated with less favorable responses to additional stress-exposure later on. Alprazolam was associated with a significant attenuation of the HPA-re sponse, suggesting a possible link between initial HPA-axis response disruption and the subsequent unfavorable outcomes.
PMID: 19167197 [PubMed - as supplied by publisher] (Source: European Neuropsychopharmacology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/02/17/alprazolam-treatment-immediately-after-stress-exposure-interferes-with-the-normal-hpa-stress-response-and-increases-vulnerability-to-subsequent-stress-in-an-animal-model-of-ptsd/feed/ 0 An evaluation of data for 10 children born to mothers who attempted suicide by taking large doses of alprazolam during pregnancy http://medsnetic.com/blog/2010/02/14/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy/ http://medsnetic.com/blog/2010/02/14/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy/#comments Sun, 14 Feb 2010 20:07:39 +0000 drugs http://medsnetic.com/blog/2010/02/14/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy/ The objective of thi s study was to evaluate the effects on fetal development of very large doses of alprazolam that were used for suicide attempts during pregnancy. Pregnant women were iden tified among the patients of the Department of Toxicology Internal Medicine, Korányi Hospital, Budapest, who were admitted as self-poisoned subjects from a total population of the three million people of Budapest and its surrounding region. Rates of congenital abnormalities, intrauterine fetal development, and cognitive-behavioral status were compared between children born to mothers who attempted suicide during pregnancy using alprazolam alone or in combination with other drugs and in their sib controls. Between 1984 and 1993, 559 pregnant women attempted suicide during pregnancy with drugs: 30 o…

]]> http://medsnetic.com/blog/2010/02/14/an-evaluation-of-data-for-10-children-born-to-mothers-who-attempted-suicide-by-taking-large-doses-of-alprazolam-during-pregnancy/feed/ 0 Actavis Launches Alprazolam ER Tablets In The U.S. http://medsnetic.com/blog/2010/02/14/actavis-launches-alprazolam-er-tablets-in-the-u-s-2/ http://medsnetic.com/blog/2010/02/14/actavis-launches-alprazolam-er-tablets-in-the-u-s-2/#comments Sun, 14 Feb 2010 11:15:20 +0000 drugs http://medsnetic.com/blog/2010/02/14/actavis-launches-alprazolam-er-tablets-in-the-u-s-2/ Actavis Group (IC EX: ACT), the international generic pharmaceuticals company, today announced that it has received approval from the U.S. Food & Drug Administration to market Alprazolam ER tablets. Distribution of the product will commence in coming weeks. Alprazolam ER tablets, the generic equivalent of Pfizer’s Xanax(R) XR tablets, will be available in 0. [click link for full article] (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/02/14/actavis-launches-alprazolam-er-tablets-in-the-u-s-2/feed/ 0 Analytical study proving alprazolam degradation to its main impurity triazolaminoquinoleine through Maillard reaction. http://medsnetic.com/blog/2010/02/09/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction/ http://medsnetic.com/blog/2010/02/09/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction/#comments Tue, 09 Feb 2010 21:56:51 +0000 drugs http://medsnetic.com/blog/2010/02/09/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction/ Au thors: Huidobro AL, Barbas C
Triazolaminoquinoleine is rapidly formed in formulations of alprazolam tablets in presence of excipients, and its generation is speeded up with increasing temperature and humidity. The present paper deals with detailed quantitative and qualitative studies into the nonactive constituents of the formulation in order to determine the excipient (or the mixture) responsible for the degradation. Our studies have demonstrated that reducing carbohydrate excipients play a fundamental role in the generation of triazolaminoquinoleine, with lacto se as the main one responsible, through a Maillard reaction. In order to demonstrate the validity of the proposed degradation mechanism, p-nitrobenzaldehyde has been employed as a model of reaction of the nucleophylic attack …

]]> http://medsnetic.com/blog/2010/02/09/analytical-study-proving-alprazolam-degradation-to-its-main-impurity-triazolaminoquinoleine-through-maillard-reaction/feed/ 0 Alprazolam induced conformational change in hemoglobin. http://medsnetic.com/blog/2010/02/07/alprazolam-induced-conformational-change-in-hemoglobin/ http://medsnetic.com/blog/2010/02/07/alprazolam-induced-conformational-change-in-hemoglobin/#comments Sun, 07 Feb 2010 13:38:44 +0000 drugs http://medsnetic.com/blog/2010/02/07/alprazolam-induced-conformational-change-in-hemoglobin/ Authors: Maitra S, Saha B, Santra CR, Mukherjee A, Goswami S, Chanda PK, Karmakar P
Alprazolam (ALP) is a widely prescribed sedative and antidepressant benzodiazepine group of drugs. The wide uses of this drug lead us to investigate its possible interaction with hemoglobin (Hb). Spectrophotometric and spectofluorimetric studies showed strong binding of ALP wi th Hb. Circular dichroic spectra showed that alpha-helical structure of Hb-subunits has been largely changed. On ALP treatment partial pressure of O(2) is increased in the blood indicating release of O(2) from erythrocytes. Further, the bin ding of ALP-induced conformational changes in Hb resulting in larger Hb particle size was demonstrated by dynamic light scattering experiment. Thus, the present study unambiguously raises questio…

]]> http://medsnetic.com/blog/2010/02/07/alprazolam-induced-conformational-change-in-hemoglobin/feed/ 0 Actavis Launches Alprazolam ER Tablets In The U.S. http://medsnetic.com/blog/2010/02/06/actavis-launches-alprazolam-er-tablets-in-the-u-s/ http://medsnetic.com/blog/2010/02/06/actavis-launches-alprazolam-er-tablets-in-the-u-s/#comments Sat, 06 Feb 2010 16:52:31 +0000 drugs http://medsnetic.com/blog/2010/02/06/actavis-launches-alprazolam-er-tablets-in-the-u-s/ Actavis Group (ICEX: ACT), the international generic pharmaceuticals company, today announced that it has received approval from the U.S. Food & Drug Administration to market Alprazolam ER tablets. Distribution of the product will commence in coming weeks. Alprazolam ER tablets, the generic equivalent of Pfizer’s Xanax(R) XR tab lets, will be available in 0.5 mg, 1 mg, 2 mg, and 3 mg strengths. [click link for full article] (Source: Anxiety News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/02/06/actavis-launches-alprazolam-er-tablets-in-the-u-s/feed/ 0 Cognitive style, alprazolam plasma levels, and treatment response in panic disorder http://medsnetic.com/blog/2010/02/06/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder/ http://medsnetic.com/blog/2010/02/06/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder/#comments Sat, 06 Feb 2010 14:45:42 +0000 drugs http://medsnetic.com/blog/2010/02/06/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder/ This study investigated an anxiety-prone cognitive style (measured by the Anxious Thoughts and Tendencies Questionnaire, AT&T) as a p redictor of the acute response to increasing alprazolam plasma levels in panic disorder. Panic disorder patients (n=26) were treated with escalating doses of alprazolam for 4 weeks, then a fixed dose of 1 mg four times a day for 4 weeks. At 0, 1, 2, 3, 4, 6, and 8 weeks, trough alprazolam plasma levels; clinical, self-report, and performance measures; and vital signs were assessed. Panic attack data were from daily diaries. The repeated response measures were analyzed in relation to alprazolam plasma levels using SAS GENMOD, w ith patients classified as high or low on the baseline AT&T. Panic attacks, anticipatory anxiety, fear, avoidance, overall agoraphobia,…

]]> http://medsnetic.com/blog/2010/02/06/cognitive-style-alprazolam-plasma-levels-and-treatment-response-in-panic-disorder/feed/ 0 Caffeine augments Alprazolam induced cytotoxicity in human cell lines. http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/ http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/#comments Sat, 06 Feb 2010 12:50:44 +0000 drugs http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/ Auth ors: Saha B, Mukherjee A, Samanta S, Saha P, Ghosh AK, Santra CR, Karmakar P
Combined effects of alprazolam (Alp), a member of benzodiazepine group of drugs and caffeine on human cell lines, HeLa and THP1 were investigated in this study. Alp mediated cytotoxicity was enhanced while caffeine was present. The cell death was confirmed by observing morphological changes, LDH assay and membrane anisotropic study. Also such combined effects induced elevated level of ROS and depletion of GSH. The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associat ed with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3. Our results indicate that, Alp alone induces apoptosis in human…

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

]]> http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/feed/ 0