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Posts Tagged ‘analysis’

Direct analysis of pharmaceutical tablet formulations using Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging.

Monday, June 7th, 2010

Authors: Earnshaw CJ, Carolan VA, Richards DS, Clench MR
Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging (MALDI MSI) has been used to directly analyse a range of tablets in or der to assess the homogeneity of the active drug compound throughout the excipients contained within the tablets studied. The information gained from the imaging experiments can be used to improve and gain a grea ter understanding of the manufacturing (more…)

An effect-size analysis of pharmacologic treatments for generalized anxiety disorder

Monday, May 31st, 2010

Generalized anxiety disorder (GAD) is a prevalent and impairing disorder, associated with extensive psychiatric and medical comorbidity and usually characterized by a chronic course. Different drugs have been investigated in GAD; among them are the following: 1) SSRIS: paroxetine, sertraline, fluvoxamine and escitalopram; 2) SNRI1S: venlafaxine; 3) benzodiaze pines (BZS): alprazolam, diazepam and lorazepam; 4) azapirones (AZAS): buspirone; 5) (more…)

Hair analysis to demonstrate administration of sildenafil to a woman in a case of drug-facilitated sexual assault. – Kintz P, Evans J, Villain M, Chatterton C, Cirimele V.

Monday, May 31st, 2010

The drug sildenafil (Viagra, Pfizer) and, more recently, tadalafil (Cialis, Lilly-Icos) and vardenafil (Levitra, Bayer), has drawn public attention to aphrodisiacs. The search for such substances dates back millennia. Adverse effects associated with these … (Source: SafetyLit: All (Unduplicated))

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A rapid CZE method for the analysis of benzodiazepines in spiked beverages

Monday, May 31st, 2010

A rapid CZE method was developed for the simultaneous determination of nine benzodiazepines in spiked beverages (nitrazepam oxazepam, alprazolam, flunitrazepam, temazepam, diazepam, 7-aminoflunitrazepam, 7-aminonitrazepam and 7-aminoclonazepam). The method employed a double-coated capillary coated with poly(diallyldimethylammonium chloride) and then dextran sulphate. The BGE conditions were 100 mM ammonium phosphate buffer, pH 2.5, which gave (more…)

Direct analysis of pharmaceutical tablet formulations using Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging.

Saturday, May 29th, 2010

Authors: Earnshaw CJ, Carolan VA, Richards DS, Clench MR
Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging (MALDI MSI) has been used to directly analyse a range of tablets in order to assess the homogeneity of the active drug compound throughout the excipients contained within the tablets studied. The information gained from the imaging experiments can be used to im prove and gain a greater understanding of the manufacturing (more…)

Review: Benzodiazepines in generalized anxiety disorder: heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials

Friday, May 21st, 2010

The objective of this study was to assess the effectiveness and efficacy of benzodiazepines in the treatment of GAD based on trial drop-out rates. We used a systematic review of randomized controlled trials that compared any of the thr ee best established benzodiazepines (diazepam, Lorazepam and aLprazolam) against placebo. Our primary outcome for effectiveness was withdrawal for any reason. Our secondary (more…)

Viamedic.com Performs Cost Comparison Analysis for Erectile Dysfunction Drugs in 50 States & 150 Cities

Friday, May 21st, 2010

Viamedic.com collected prices for FDA-approved Viagr a, Cialis and Levitra at CVS pharmacies (Fred Meyer/Safeway in Alaska and Hawaii) from the three most populous cities in all 50 U.S. states. The results revealed that Viamedic.com charges an average of about $20 more than it would cost if a consumer went to their local doctor. However, many consumers appreciate the convenience and additional benefit of using an online pharmacy instead of dealing (more…)

Hair analysis to demonstrate administration of sildenafil to a woman in a case of drug-facilitated sexual assault. – Kintz P, Evans J, Villain M, Chatterton C, Cirimele V.

Tuesday, April 20th, 2010

The drug sildena fil (Viagra, Pfizer) and, more recently, tadalafil (Cialis, Lilly-Icos) and vardenafil (Levitra, Bayer), has drawn public attention to aphrodisiacs. The search for such substances dates back millennia. Adverse effects associated with these … (Source: SafetyLit: All (Unduplicated))

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative (more…)

A rapid CZE method for the analysis of benzodiazepines in spiked beverages

Thursday, February 18th, 2010

A rapid CZE met hod was developed for the simultaneous determination of nine benzodiazepines in spiked beverages (nit razepam oxazepam, alprazolam, flunitrazepam, temazepam, diazepam, 7-aminoflunitrazepam, 7-aminonitrazepam and 7-aminoclonazepam). The method employed a double-coated capillary coated with poly(diallyldimethylammonium chloride) and then dextran sulphate. The BGE conditions were 100 mM ammonium phosphate buffer, pH 2.5, which gave (more…)

Viamedic.com Performs Cost Comparison Analysis for Erectile Dysfunction Drugs in 50 States & 150 Cities

Sunday, February 14th, 2010

Viamedic.com collected prices for FDA-approved Viagra, Cialis and Levitra at CVS pharmacies (Fred Meyer/Safeway in Alaska and Hawaii) from the three most populous cities in all 50 U.S. states. The results revealed that Viamedic.com charges an average of about $20 more than it would c ost if a consumer went to their local doctor. However, many consumers appreciate the convenience and additional benefit of using an online pharmacy instead of dealing (more…)

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