Online Pharmacy US » anxiety http://medsnetic.com/blog Viagra, Xanax, Cialis, Phentermine, Levitra Sat, 04 Sep 2010 14:36:15 +0000 http://wordpress.org/?v=2.9.2 en hourly 1 Sun Pharma receives USFDA nod for anti-anxiety drug http://medsnetic.com/blog/2010/08/04/sun-pharma-receives-usfda-nod-for-anti-anxiety-drug/ http://medsnetic.com/blog/2010/08/04/sun-pharma-receives-usfda-nod-for-anti-anxiety-drug/#comments Wed, 04 Aug 2010 13:40:14 +0000 drugs http://medsnetic.com/blog/2010/08/04/sun-pharma-receives-usfda-nod-for-anti-anxiety-drug/ Sun Pharmaceutical Industries today said that it has received the US Food and Drug Administration’s nod to market a generic version of alprazolam, an anti-anxiety drug, in the US market. (Source: The Economic Times Healthcare and Biotech News)

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]]> http://medsnetic.com/blog/2010/08/04/sun-pharma-receives-usfda-nod-for-anti-anxiety-drug/feed/ 0 Despite Known Health Risks Long-Term Use Of Anti-Anxiety Drugs Continues In B.C. http://medsnetic.com/blog/2010/06/06/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c-2/ http://medsnetic.com/blog/2010/06/06/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c-2/#comments Sun, 06 Jun 2010 00:56:49 +0000 drugs http://medsnetic.com/blog/2010/06/06/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c-2/ Drugs to treat anxiety and sleep disorders are still being prescribed for extended periods to British Columbian patients – and i ncreasingly so for baby boomers – despite warnings against long-term use, according to a University of British Columbia study. Published online in the journal Health Policy, the study by researchers at UBC’s Centre for Health Services and Policy Research (CHSPR) is the first of its kind to examine the use of benzodiazepines such as Xanax and Ativan for an entire population over time… (Source: Health News from Medical News Today)

]]> http://medsnetic.com/blog/2010/06/06/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c-2/feed/ 0 An effect-size analysis of pharmacologic treatments for generalized anxiety disorder http://medsnetic.com/blog/2010/05/31/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder-2/ http://medsnetic.com/blog/2010/05/31/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder-2/#comments Mon, 31 May 2010 23:53:10 +0000 drugs http://medsnetic.com/blog/2010/05/31/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder-2/ Generalized anxiety disorder (GAD) is a prevalent and impairing disorder, associated with extensive psychiatric and medical comorbidity and usually characterized by a chronic course. Different drugs have been investigated in GAD; among them are the following: 1) SSRIS: paroxetine, sertraline, fluvoxamine and escitalopram; 2) SNRI1S: venlafaxine; 3) benzodiaze pines (BZS): alprazolam, diazepam and lorazepam; 4) azapirones (AZAS): buspirone; 5) antihistamines (AHS): hydroxyzine; 6) pregabalin (PGB); and 7) complementary/alternative medicine (CAM): kava-kava and homeopathic preparation. We conducted an effect size (ES) analysis of 21 double-blind placebo-controlled tr ials of medications treating DSM-III-R, DSM-IV or ICD-10 GAD using HAM-A change in score from baseline or endpoint score as the …

]]> http://medsnetic.com/blog/2010/05/31/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder-2/feed/ 0 Anxiety Medications http://medsnetic.com/blog/2010/05/30/anxiety-medications-2/ http://medsnetic.com/blog/2010/05/30/anxiety-medications-2/#comments Sun, 30 May 2010 10:45:00 +0000 drugs http://medsnetic.com/blog/2010/05/30/anxiety-medications-2/ Antianxiety medications help to calm and relax the anxious person and remove the troubling symptoms. There are a number of antianxiety medications currently available. The preferred medications for most anxiety disorders are the benzodiazepines such as Valium, Xanax/Zanex, and Ativan. (Source: About.com Mental Health)

]]> http://medsnetic.com/blog/2010/05/30/anxiety-medications-2/feed/ 0 Erratum to: Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/#comments Sat, 29 May 2010 13:10:11 +0000 drugs http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Ut recht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsE. P. Prinssen, CNS Research, F. Hoffmann-La Roche, Clinical Development Basel SwitzerlandI. Niklson, CNS Research, F. Hoffmann-La Roche, Clinical Development Base l SwitzerlandC. Xia-Chen, Centre for Human Drug Resear…

]]> http://medsnetic.com/blog/2010/05/29/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/feed/ 0 Despite Known Health Risks Long-Term Use Of Anti-Anxiety Drugs Continues In B.C. http://medsnetic.com/blog/2010/05/28/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c/ http://medsnetic.com/blog/2010/05/28/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c/#comments Fri, 28 May 2010 11:13:26 +0000 drugs http://medsnetic.com/blog/2010/05/28/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c/ Drugs to treat anxiety and sleep disorders are still being prescribed for extended periods to British Columbian patients – and increasingly so for baby boomers – despite warnings against long-term use, according to a University of British Columbi a study. Published online in the journal Health Policy, the study by researchers at UBC’s Centre for Health Services and Policy Research (CHSPR) is the first of its kind to examine the use of benzodiazepines such as Xanax and Ativan for an entire population over time… (Source: Health News from Medical News Today)

]]> http://medsnetic.com/blog/2010/05/28/despite-known-health-risks-long-term-use-of-anti-anxiety-drugs-continues-in-b-c/feed/ 0 Early onset anxiolytic efficacy after a single dose of pregabalin: double-blind, placebo- and active-comparator controlled evaluation using a dental anxiety model http://medsnetic.com/blog/2010/05/26/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model-2/ http://medsnetic.com/blog/2010/05/26/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model-2/#comments Wed, 26 May 2010 15:13:20 +0000 drugs http://medsnetic.com/blog/2010/05/26/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model-2/ To evaluate acute onset of anxiolytic activity using a dental anxiety model, 89 patients were randomised to double-blind single dose pregabalin 150 mg, alprazolam 0.5 mg or placebo 4 h before a scheduled dental procedure. A Dental Anxiety Total score >12 (moderate-to-severe) without meeting Diagnostic and Statistical Manual of Mental Di sorders (Fourth edition) (DSM-IV) anxiety disorder criteria was required. Efficacy and safety, assessed 2, 2.5, 3, 3.5 and 4 h postdose, included 100 mm Visual Analogue Scale for Anxiety (VAS -Anxiety; primary outcome), 100 mm VAS-Sedation and Time-to-Onset of Action Scale (TOAS), a patient-rated anti-anxiety drug-benefit scale (no [0] to full benefit [10]). Mixed model analysis found significantly greater VAS-A improvement slopes for pregabalin (t = &ndas…

]]> http://medsnetic.com/blog/2010/05/26/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model-2/feed/ 0 Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/#comments Sat, 22 May 2010 20:05:08 +0000 drugs http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/ Conclusion  Even though fear-potentiated startle may be used to translate preclini cal evidence to human populations, methodological issues
still hamper the application of this model to early screening of putative anxiolytic drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht Univer sity Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Hei…

]]> http://medsnetic.com/blog/2010/05/22/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine-2/feed/ 0 A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/ http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/#comments Fri, 21 May 2010 14:51:22 +0000 drugs http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/ In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of a nxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A receptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which are now in early phase clinical studies and are showing selective efficacy in pharmacodynamic studies. (Source: Journal of Psychopharmacology)

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]]> http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/feed/ 0 Review: Benzodiazepines in generalized anxiety disorder: heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials http://medsnetic.com/blog/2010/05/21/review-benzodiazepines-in-generalized-anxiety-disorder-heterogeneity-of-outcomes-based-on-a-systematic-review-and-meta-analysis-of-clinical-trials-2/ http://medsnetic.com/blog/2010/05/21/review-benzodiazepines-in-generalized-anxiety-disorder-heterogeneity-of-outcomes-based-on-a-systematic-review-and-meta-analysis-of-clinical-trials-2/#comments Fri, 21 May 2010 01:33:33 +0000 drugs http://medsnetic.com/blog/2010/05/21/review-benzodiazepines-in-generalized-anxiety-disorder-heterogeneity-of-outcomes-based-on-a-systematic-review-and-meta-analysis-of-clinical-trials-2/ The objective of this study was to assess the effectiveness and efficacy of benzodiazepines in the treatment of GAD based on trial drop-out rates. We used a systematic review of randomized controlled trials that compared any of the thr ee best established benzodiazepines (diazepam, Lorazepam and aLprazolam) against placebo. Our primary outcome for effectiveness was withdrawal for any reason. Our secondary outcome tapping efficacy was withdrawal due to lack of efficacy, and that tapping side effects was withdrawals due to adverse events.We included 23 trials. Pooled analysis indicated less risk of treatment discontin uation due to lack of efficacy for benzodiazepines, compared to placebo, relative risk (RR) 0.29 (95% CI 0…

]]> http://medsnetic.com/blog/2010/05/21/review-benzodiazepines-in-generalized-anxiety-disorder-heterogeneity-of-outcomes-based-on-a-systematic-review-and-meta-analysis-of-clinical-trials-2/feed/ 0 Treatments for Anxiety http://medsnetic.com/blog/2010/05/20/treatments-for-anxiety-2/ http://medsnetic.com/blog/2010/05/20/treatments-for-anxiety-2/#comments Thu, 20 May 2010 11:05:46 +0000 drugs http://medsnetic.com/blog/2010/05/20/treatments-for-anxiety-2/ Anxiety is a well-understood and readily treated condition. There are many different kinds of specific anxiety disorders, ranging from generalized anxiety disorder (GAD) to panic attacks. The below treatment options cover general anxiety disorders and are usually recomme nded in some combination.
Medications
The medications most often used to treat anxiety are a class of drugs known as benzodiazepines (also called “minor tranquilizers”). These include Xana x, Ativan and Klonopin. The primary concern with these substances is their potential for tolerance, physical dependence, and the likely recurrence of panic and anxiety symptoms when the medication is stopped. Hence, they are best used for treating short-term anxiety and panic. Because anxiety is so often associated with depre…

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]]> http://medsnetic.com/blog/2010/05/20/treatments-for-anxiety-2/feed/ 0 Chimpanzee Was On Anti-Anxiety Drug Xanax http://medsnetic.com/blog/2010/05/18/chimpanzee-was-on-anti-anxiety-drug-xanax-2/ http://medsnetic.com/blog/2010/05/18/chimpanzee-was-on-anti-anxiety-drug-xanax-2/#comments Tue, 18 May 2010 20:35:02 +0000 drugs http://medsnetic.com/blog/2010/05/18/chimpanzee-was-on-anti-anxiety-drug-xanax-2/ Travis the chimpanzee — whose presence in a Stamford home had been called an “accident waiting to happen” months before he attacked Charla Nash — had the anti-anxiety drug Xanax in his system, according to the state’s attorney’s office.

It is… (Source: OrlandoSentinel: Medical Research)

]]> http://medsnetic.com/blog/2010/05/18/chimpanzee-was-on-anti-anxiety-drug-xanax-2/feed/ 0 Erratum to: Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/#comments Mon, 26 Apr 2010 13:44:17 +0000 drugs http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social S ciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsE. P. Prinssen, CNS Research, F. Hoffmann-La Roche, Clinical Development Basel SwitzerlandI. Niklson, CNS Research, F. Hoffmann-La Roch e, Clinical Development Basel SwitzerlandC. Xia-Chen, Centre for Human Drug Resear…

]]> http://medsnetic.com/blog/2010/04/26/erratum-to-validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/feed/ 0 Medications for Anxiety http://medsnetic.com/blog/2010/03/06/medications-for-anxiety/ http://medsnetic.com/blog/2010/03/06/medications-for-anxiety/#comments Sat, 06 Mar 2010 02:03:40 +0000 drugs http://medsnetic.com/blog/2010/03/06/medications-for-anxiety/ Medications for anxiet y benzodiazepines clonazepam Klonopin alprazolam Xanax diazepam Valium lorazepam Ativan buspirone buspar propranolol Inderal Inderide (Source: About.com Mental Health)

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]]> http://medsnetic.com/blog/2010/03/06/medications-for-anxiety/feed/ 0 Anxiety Medications http://medsnetic.com/blog/2010/03/02/anxiety-medications/ http://medsnetic.com/blog/2010/03/02/anxiety-medications/#comments Tue, 02 Mar 2010 23:13:15 +0000 drugs http://medsnetic.com/blog/2010/03/02/anxiety-medications/ Antianxiety medications help to calm and relax the anxious person and remove the troubling symptoms. There are a n umber of antianxiety medications currently available. The preferred medications for most anxiety disorders are the benzodiazepines such as Valium, Xanax/Zanex, and Ativan. (Source: About.com Mental Health)

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]]> http://medsnetic.com/blog/2010/03/02/anxiety-medications/feed/ 0 Chimpanzee Was On Anti-Anxiety Drug Xanax http://medsnetic.com/blog/2010/03/01/chimpanzee-was-on-anti-anxiety-drug-xanax/ http://medsnetic.com/blog/2010/03/01/chimpanzee-was-on-anti-anxiety-drug-xanax/#comments Mon, 01 Mar 2010 23:51:20 +0000 drugs http://medsnetic.com/blog/2010/03/01/chimpanzee-was-on-anti-anxiety-drug-xanax/ Travis the chimpanzee — whose presence in a Stamford home had been called an “accident waiting to happen” months before he attacked Charla Nash — had the anti-anxiety drug Xanax in his system, according to the state’s attorney’s office.

It is… (Source: OrlandoSentinel: Medical Research)

]]> http://medsnetic.com/blog/2010/03/01/chimpanzee-was-on-anti-anxiety-drug-xanax/feed/ 0 Treatments for Anxiety http://medsnetic.com/blog/2010/02/20/treatments-for-anxiety/ http://medsnetic.com/blog/2010/02/20/treatments-for-anxiety/#comments Sat, 20 Feb 2010 01:24:58 +0000 drugs http://medsnetic.com/blog/2010/02/20/treatments-for-anxiety/ Anxiety is a well-understood and readily treated condition. T here are many different kinds of specific anxiety disorders, ranging from generalized anxiety disorder (GAD) to panic attacks. The below treatment options cover general anxiety disorders and are usually recommended in some combination.
Medications
The medications most often used to treat anxiety are a class of drugs known as benzodiazepines (also called “minor tranquilizers”). These include Xanax, Ativan and Klonopin. The primary concern with these substances is their potential for tolerance, physical dependence, and the likely recurrence of panic and anxiety symptoms when the medication is stopped. Hence, they are best used for treating short-term anxiety and panic. Because an xiety is so often associated with depre…

]]> http://medsnetic.com/blog/2010/02/20/treatments-for-anxiety/feed/ 0 Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/#comments Wed, 17 Feb 2010 17:49:05 +0000 drugs http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/ Conclusion  Even though fear-potentiated startle may be used to translate preclinical evidence to human populations, methodological issues
still hamper the application of this model to early screening of putative anxiolytic drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht Univ ersity Department of Experimental Psychology, Faculty of Social Scien ces Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Hei…

]]> http://medsnetic.com/blog/2010/02/17/validating-a-human-model-for-anxiety-using-startle-potentiated-by-cue-and-context-the-effects-of-alprazolam-pregabalin-and-diphenhydramine/feed/ 0 A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/ http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/#comments Tue, 16 Feb 2010 08:55:34 +0000 drugs http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/ In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of anxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A rec eptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which are now in early phase clinical studies and are showing selective efficacy in pharmacodynamic studies. (Source: Journal of Psychopharmacology)

]]> http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/feed/ 0 Early onset anxiolytic efficacy after a single dose of pregabalin: double-blind, placebo- and active-comparator controlled evaluation using a dental anxiety model http://medsnetic.com/blog/2010/02/14/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model/ http://medsnetic.com/blog/2010/02/14/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model/#comments Sun, 14 Feb 2010 05:00:35 +0000 drugs http://medsnetic.com/blog/2010/02/14/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model/ To evaluate acute onset of anxiolytic activity using a dental anxiety model, 89 patients were randomised to double-blind single dose pregabalin 150 mg, alprazolam 0.5 mg or placebo 4 h before a scheduled dental procedure. A Dental Anxiety Total score >12 (moderate-to-severe) without meeting Diagnostic and Statistical Manual of Mental Disorders (Fourth edition) (DSM-IV) anxiety disorder criteria was required. Efficacy and safety, asse ssed 2, 2.5, 3, 3.5 and 4 h postdose, included 100 mm Visual Analogue Scale for Anxiety (VAS-Anxiety; primary outcome), 100 mm VAS-Sedation and Time-to-Onset of Action Scale (TOAS), a patient-rated anti-anxiety drug-benefit scale (no [0] to full benefit [10]). Mixed model analysis found significantly greater V AS-A improvement slopes for pregabalin (t = &ndas…

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]]> http://medsnetic.com/blog/2010/02/14/early-onset-anxiolytic-efficacy-after-a-single-dose-of-pregabalin-double-blind-placebo-and-active-comparator-controlled-evaluation-using-a-dental-anxiety-model/feed/ 0 An effect-size analysis of pharmacologic treatments for generalized anxiety disorder http://medsnetic.com/blog/2010/02/12/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder/ http://medsnetic.com/blog/2010/02/12/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder/#comments Fri, 12 Feb 2010 23:00:18 +0000 drugs http://medsnetic.com/blog/2010/02/12/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder/ Generalized anxiety disorder (GAD) is a prevalent and impairing disorder, associated with extensive psychiatric and medical comorbidity and usually characterized by a chronic course. Different drugs have been investigated in GAD; among them are the followin g: 1) SSRIS: paroxetine, sertraline, fluvoxamine and escitalopram; 2) SNRI1S: venlafaxine; 3) benzodiazepines (BZS): alprazolam, diazepam and lorazepam; 4) azapirones (AZAS): buspirone; 5) antihistamines (AH S): hydroxyzine; 6) pregabalin (PGB); and 7) complementary/alternative medicine (CAM): kava-kava and homeopathic preparation. We conducted an effect size (ES) analysis of 21 double-blind placebo-controlled trials of medications treating DSM-III-R, DSM-IV or ICD-10 GAD using HAM-A change in score from baseline or endpoint score as the …

]]> http://medsnetic.com/blog/2010/02/12/an-effect-size-analysis-of-pharmacologic-treatments-for-generalized-anxiety-disorder/feed/ 0 Review: Benzodiazepines in generalized anxiety disorder: heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials http://medsnetic.com/blog/2010/02/10/review-benzodiazepines-in-generalized-anxiety-disorder-heterogeneity-of-outcomes-based-on-a-systematic-review-and-meta-analysis-of-clinical-trials/ http://medsnetic.com/blog/2010/02/10/review-benzodiazepines-in-generalized-anxiety-disorder-heterogeneity-of-outcomes-based-on-a-systematic-review-and-meta-analysis-of-clinical-trials/#comments Wed, 10 Feb 2010 23:29:10 +0000 drugs http://medsnetic.com/blog/2010/02/10/review-benzodiazepines-in-generalized-anxiety-disorder-heterogeneity-of-outcomes-based-on-a-systematic-review-and-meta-analysis-of-clinical-trials/ The objective of this study was to assess the effectiveness and efficacy of benzodiazepines in the treatment of GAD based on trial drop-out rates. We used a systematic review of randomized controlled tr ials that compared any of the three best established benzodiazepines (diazepam, Lorazepam and aLprazolam) against placebo. Our primary outcome for effectiveness was withdrawal for any reason. Our secondary outcome tapping efficacy was withdrawal due to lack of efficacy, and that tapping side effects was withdrawals due to adverse events.We included 23 trials. Pooled analysis indicated less risk of treatment discontinuation due to lack of efficacy for benzodiazepines, compared to placebo, relative risk (RR) 0.29 (95% CI 0…

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