Online Pharmacy US » assisted http://medsnetic.com/blog Viagra, Xanax, Cialis, Phentermine, Levitra Fri, 10 Sep 2010 21:39:18 +0000 http://wordpress.org/?v=2.9.2 en hourly 1 Direct analysis of pharmaceutical tablet formulations using Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging. http://medsnetic.com/blog/2010/06/07/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging-2/ http://medsnetic.com/blog/2010/06/07/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging-2/#comments Mon, 07 Jun 2010 14:10:57 +0000 drugs http://medsnetic.com/blog/2010/06/07/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging-2/ Authors: Earnshaw CJ, Carolan VA, Richards DS, Clench MR
Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging (MALDI MSI) has been used to directly analyse a range of tablets in or der to assess the homogeneity of the active drug compound throughout the excipients contained within the tablets studied. The information gained from the imaging experiments can be used to improve and gain a grea ter understanding of the manufacturing process; such knowledge will enable improvements in finished product quality to make safer and more efficacious tablet formulations. Commercially available and prescription tablet formulations have been analysed, including aspirin, paracetamol, sildenafil citrate (Viagra(R)) and a batch of tablets in development (tablet X: placebo; 1 mg; 3 mg and…

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]]> http://medsnetic.com/blog/2010/06/07/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging-2/feed/ 0 Direct analysis of pharmaceutical tablet formulations using Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging. http://medsnetic.com/blog/2010/05/29/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging/ http://medsnetic.com/blog/2010/05/29/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging/#comments Sat, 29 May 2010 15:13:02 +0000 drugs http://medsnetic.com/blog/2010/05/29/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging/ Authors: Earnshaw CJ, Carolan VA, Richards DS, Clench MR
Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging (MALDI MSI) has been used to directly analyse a range of tablets in order to assess the homogeneity of the active drug compound throughout the excipients contained within the tablets studied. The information gained from the imaging experiments can be used to im prove and gain a greater understanding of the manufacturing process; such knowledge will enable improvements in finished product quality to make safer and more efficacious tablet formulations. Commercially available and prescription tablet formulations have been analysed, including aspirin, paracetamol, sildenafil citrate (Viagra (R)) and a batch of tablets in development (tablet X: placebo; 1 mg; 3 mg and…

]]> http://medsnetic.com/blog/2010/05/29/direct-analysis-of-pharmaceutical-tablet-formulations-using-matrix-assisted-laser-desorptionionisation-mass-spectrometry-imaging/feed/ 0 Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma. http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/ http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/#comments Tue, 25 May 2010 13:56:58 +0000 drugs http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/ Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase extraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design was used with extraction time, temperature and solvent volume as influential parameters. A desirability function was employed in addition to the simultaneous optimization of the MAE condition s. The analysis of variance showed that the solvent volume had a positive influence on the extraction of all the analytes tested, achieving a statistically sig…

]]> http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/feed/ 0 Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma. http://medsnetic.com/blog/2010/03/08/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma/ http://medsnetic.com/blog/2010/03/08/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma/#comments Mon, 08 Mar 2010 07:18:20 +0000 drugs http://medsnetic.com/blog/2010/03/08/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma/ Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase e xtraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design was used with extraction time, temperature and solvent volume as influential parameters. A desirability function was employed in addition to the simultaneous optimization of the MAE conditions. The analysis of variance showed that the solvent volume had a positive influence on the extraction of all the analytes tested, achieving a statistically sig…

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