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A rapid CZE method was developed for the simultaneous determination of nine benzodiazepines in spiked beverages (nitrazepam oxazepam, alprazolam, flunitrazepam, temazepam, diazepam, 7-aminoflunitrazepam, 7-aminonitrazepam and 7-aminoclonazepam). The method employed a double-coated capillary coated with poly(diallyldimethylammonium chloride) and then dextran sulphate. The BGE conditions were 100 mM ammonium phosphate buffer, pH 2.5, which gave (more…)

Previous studies in our laboratory sho wed that cannabinoid CB1 receptor knockout mice (CB1-/-) presented increased anxiety-like behaviours that did not respond to the anxiolytic actions of benzodiazepines. These results suggest that the pharmacological effects of benzodiazepines may involve the participation of cannabinoid CB1 receptors. Therefore, the purpose of t his study was to examine the effects of alprazolam and the cannabinoid CB1 receptor (more…)

Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase extraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design (more…)

Authors: Nakamura M, Ohmori T, Itoh Y, Terashita M, Hirano K
A liquid chromatography-tandem ma ss spectrometry (LC-MS/MS) method using a high-resolution octa decyl silica column compatible with aqueous compounds was developed for the simultaneous determination of benzodiazepines and their metabolites in human serum. This method enabled us to determine multiple benzodiazepines, including flurazepam, bromazepam, chlordiazepoxide, nitrazepam, (more…)

In conclusion, Alprazolam, Bromazepam, Chlordiazepoxide, Clonazepam, Di azepam, Lorazepam, Nitrazepam, Oxazepam, Tetrazepam and Triazolam can be considered as safe drugs in term of their inability to induce PXR- and AhR-dependent cytochrome P450 enzymes CYP1A2 and CYP3A4. Medazepam and Midazolam slightly activated pregnane X receptor and displayed weak potency to induce CYP3A4 mRNA in human hepatocytes.
PMID: 20080160 [PubMed – as supplied (more…)

The objective of this study was to assess the effectiveness and efficacy of benzodiazepines in the treatment of GAD based on trial drop-out rates. We used a systematic review of randomized controlled trials that compared any of the thr ee best established benzodiazepines (diazepam, Lorazepam and aLprazolam) against placebo. Our primary outcome for effectiveness was withdrawal for any reason. Our secondary (more…)

Abstract
Introduction  The effects of pre-conditioning administration of anxiolytic benzodiazepines on the acquisition of a conditioned taste aversion
(CTA) and on the acquisition of attenuation of neophobia (AN) were investigated in C57BL/6 mice.

M aterials and methods  A CTA was induced by injecting lithium chloride (LiCl; 6 mEq
.
kg−1) 30 min after the animal had imbibed a novel 0.5% saccharin (more…)

Information about the benzodiazepine family of medications, generally used to treat anxiety and related conditions, including Valium, Librium, Xanax and several others. (Source: About.com Bipolar Disorder)

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Previous studies in our laboratory showed that cannabinoid CB1 receptor knockout mice (CB1-/-) presented increased anxiety-like behaviours that did not resp ond to the anxiolytic actions of benzodiazepines. These results suggest that the pharmacological effects of benzod iazepines may involve the participation of cannabinoid CB1 receptors. Therefore, the purpose of this study was to examine the effects of alprazolam and the cannabinoid CB1 receptor (more…)

Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase e xtraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design (more…)