Online Pharmacy US » cell http://medsnetic.com/blog Viagra, Xanax, Cialis, Phentermine, Levitra Fri, 10 Sep 2010 21:39:18 +0000 http://wordpress.org/?v=2.9.2 en hourly 1 Sildenafil treatment in vivo stimulates Leydig cell steroidogenesis via cAMP and cGMP signaling pathway. http://medsnetic.com/blog/2010/08/01/sildenafil-treatment-in-vivo-stimulates-leydig-cell-steroidogenesis-via-camp-and-cgmp-signaling-pathway/ http://medsnetic.com/blog/2010/08/01/sildenafil-treatment-in-vivo-stimulates-leydig-cell-steroidogenesis-via-camp-and-cgmp-signaling-pathway/#comments Sun, 01 Aug 2010 19:49:07 +0000 drugs http://medsnetic.com/blog/2010/08/01/sildenafil-treatment-in-vivo-stimulates-leydig-cell-steroidogenesis-via-camp-and-cgmp-signaling-pathway/ This study was designed to assess the effects of prolonged sildenafil treatment on nitric oxide synthase (NOS)-dependent signaling and steroidogenic function of rat Leydig cells. Male adult rats were treated with Viagra (1.25 mg/kg body weight) daily, for 30 days. In our studies, serum testosterone and ex vivo testosterone production significantly increased in sildenafil-treated animals. Human chorionic gonadotropin (hCG)-stimulated testosterone production and cAMP accumulation were also significantly higher in Leydig cells obtained f rom sildenafil-treated rats. The expr ession of soluble guanylyl cyclase (GUCY1) subunits (Gucy1a1, Gucy1b1) significantly increased; cAMP specific Pde4a, cGMP specific Pde6c, dual Pde1c and Nos2, were inhibited and expression of Nos3, protein kinase 1 (Prkg1) …

]]> http://medsnetic.com/blog/2010/08/01/sildenafil-treatment-in-vivo-stimulates-leydig-cell-steroidogenesis-via-camp-and-cgmp-signaling-pathway/feed/ 0 Caffeine augments Alprazolam induced cytotoxicity in human cell lines. http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/ http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/#comments Sun, 30 May 2010 13:45:02 +0000 drugs http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/ Authors: Saha B, Mukherjee A, Samanta S, Saha P, Ghosh AK, Santra CR, Karmakar P
Combined effects of alprazolam (Alp), a member of benzodiazepine group of drugs and caffeine on human cell lines, HeLa and THP1 were investigated in this stu dy. Alp mediated cytotoxicity was enhanced while caffeine was present. The cell death was confirmed by observing morphological changes, LDH assay and membrane anisotropic study. Also such combined effects induced elevated level of ROS and depletion of GSH. The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3. Our results indicate that, Alp alon e induces apoptosis in human…

]]> http://medsnetic.com/blog/2010/05/30/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines-2/feed/ 0 Vardenafil Increases Cell Proliferation in the Dentate Gyrus through Enhancement of Serotonin Expression in the Rat Dorsal Raphe. http://medsnetic.com/blog/2010/05/28/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe-2/ http://medsnetic.com/blog/2010/05/28/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe-2/#comments Fri, 28 May 2010 14:00:15 +0000 drugs http://medsnetic.com/blog/2010/05/28/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe-2/ This study was conducted to evaluate the effects of vardenafil (Levitra), a phosphodiesterase-5 (PDE-5) inhibitor, on cell proliferation in the hippocampal dentate gyrus and on 5-hyroxytryptamine (5- HT, serotonin) synthesis and tryptophan hydroxylase (TPH) expression in the rat dorsal raphe nucleus. Male Sprague-Dawley rats were divided into 6 groups (n=5 in each group): a control group, a 0.5 mg/kg-1 day vardenafil-treated grou p, a 1 mg/kg-1 day vardenafil-treated group, a 2 mg/kg-1 day vardenafil-treated group, a 1 mg/kg-3 day vardenafil-treated group, and a 1 mg/kg-7 day vardenafil-treated group. 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry was then performed to evaluate cell proliferation in the dentate gyrus. In addition, 5-HT and TPH immunohistochemistry was conducted to evalu…

]]> http://medsnetic.com/blog/2010/05/28/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe-2/feed/ 0 Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats http://medsnetic.com/blog/2010/05/23/antiobesity-effects-of-the-i%c2%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/ http://medsnetic.com/blog/2010/05/23/antiobesity-effects-of-the-i%c2%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/#comments Sun, 23 May 2010 23:06:07 +0000 drugs http://medsnetic.com/blog/2010/05/23/antiobesity-effects-of-the-i%c2%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/ Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats

International Journal of Obesity advance online publication, June 17, 2008. doi:10.1038/ijo.2008.91

Au thors: J D Roth, J L Trevaskis, J Wilson, C Lei, J Athanacio, C Mack, N C Kesty, T Coffey, C Weyer
& D G Parkes (Source: International Journal of Obesity)

]]> http://medsnetic.com/blog/2010/05/23/antiobesity-effects-of-the-i%c2%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/feed/ 0 Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines. http://medsnetic.com/blog/2010/05/21/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines-2/ http://medsnetic.com/blog/2010/05/21/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines-2/#comments Fri, 21 May 2010 12:47:37 +0000 drugs http://medsnetic.com/blog/2010/05/21/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines-2/ In conclusion, Alprazolam, Bromazepam, Chlordiazepoxide, Clonazepam, Di azepam, Lorazepam, Nitrazepam, Oxazepam, Tetrazepam and Triazolam can be considered as safe drugs in term of their inability to induce PXR- and AhR-dependent cytochrome P450 enzymes CYP1A2 and CYP3A4. Medazepam and Midazolam slightly activated pregnane X receptor and displayed weak potency to induce CYP3A4 mRNA in human hepatocytes.
PMID: 20080160 [PubMed - as supplied by publisher] (Source: Toxicology Letters)

]]> http://medsnetic.com/blog/2010/05/21/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines-2/feed/ 2 Viagra Trial for Sickle Cell Lung Problems Halted http://medsnetic.com/blog/2010/04/20/viagra-trial-for-sickle-cell-lung-problems-halted-5/ http://medsnetic.com/blog/2010/04/20/viagra-trial-for-sickle-cell-lung-problems-halted-5/#comments Tue, 20 Apr 2010 09:01:58 +0000 drugs http://medsnetic.com/blog/2010/04/20/viagra-trial-for-sickle-cell-lung-problems-halted-5/ Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Lungs General)

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]]> http://medsnetic.com/blog/2010/04/20/viagra-trial-for-sickle-cell-lung-problems-halted-5/feed/ 0 Viagra Trial for Sickle Cell Lung Problems Halted http://medsnetic.com/blog/2010/04/02/viagra-trial-for-sickle-cell-lung-problems-halted-4/ http://medsnetic.com/blog/2010/04/02/viagra-trial-for-sickle-cell-lung-problems-halted-4/#comments Fri, 02 Apr 2010 14:10:31 +0000 drugs http://medsnetic.com/blog/2010/04/02/viagra-trial-for-sickle-cell-lung-problems-halted-4/ Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet High Blood Pressure General)

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]]> http://medsnetic.com/blog/2010/04/02/viagra-trial-for-sickle-cell-lung-problems-halted-4/feed/ 0 Viagra Trial for Sickle Cell Lung Problems Halted http://medsnetic.com/blog/2010/03/13/viagra-trial-for-sickle-cell-lung-problems-halted-3/ http://medsnetic.com/blog/2010/03/13/viagra-trial-for-sickle-cell-lung-problems-halted-3/#comments Sat, 13 Mar 2010 05:35:29 +0000 drugs http://medsnetic.com/blog/2010/03/13/viagra-trial-for-sickle-cell-lung-problems-halted-3/ Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Cancer General)

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]]> http://medsnetic.com/blog/2010/03/13/viagra-trial-for-sickle-cell-lung-problems-halted-3/feed/ 0 Viagra Trial for Sickle Cell Lung Problems Halted http://medsnetic.com/blog/2010/03/06/viagra-trial-for-sickle-cell-lung-problems-halted-2/ http://medsnetic.com/blog/2010/03/06/viagra-trial-for-sickle-cell-lung-problems-halted-2/#comments Sat, 06 Mar 2010 13:42:11 +0000 drugs http://medsnetic.com/blog/2010/03/06/viagra-trial-for-sickle-cell-lung-problems-halted-2/ Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Senior Health Genera l)

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]]> http://medsnetic.com/blog/2010/03/06/viagra-trial-for-sickle-cell-lung-problems-halted-2/feed/ 0 Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats http://medsnetic.com/blog/2010/03/03/antiobesity-effects-of-the-%ce%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/ http://medsnetic.com/blog/2010/03/03/antiobesity-effects-of-the-%ce%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/#comments Wed, 03 Mar 2010 19:31:07 +0000 drugs http://medsnetic.com/blog/2010/03/03/antiobesity-effects-of-the-%ce%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/ Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats

International Journal of Obesity advance online publicat ion, June 17, 2008. doi:10.1038/ijo.2008.91

Authors: J D Roth, J L Trevaskis, J Wilson, C Lei, J Athanacio, C Mack, N C Kesty, T Coffey, C Weyer
& D G Parkes (Source: International Journal of Obesity)

]]> http://medsnetic.com/blog/2010/03/03/antiobesity-effects-of-the-%ce%b2-cell-hormone-amylin-in-combination-with-phentermine-or-sibutramine-in-diet-induced-obese-rats/feed/ 0 Viagra Trial for Sickle Cell Lung Problems Halted http://medsnetic.com/blog/2010/03/03/viagra-trial-for-sickle-cell-lung-problems-halted/ http://medsnetic.com/blog/2010/03/03/viagra-trial-for-sickle-cell-lung-problems-halted/#comments Wed, 03 Mar 2010 06:46:42 +0000 drugs http://medsnetic.com/blog/2010/03/03/viagra-trial-for-sickle-cell-lung-problems-halted/ Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/ 29/2009 (Source: MedicineNet Mens Health General)

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]]> http://medsnetic.com/blog/2010/03/03/viagra-trial-for-sickle-cell-lung-problems-halted/feed/ 0 Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines. http://medsnetic.com/blog/2010/03/01/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines/ http://medsnetic.com/blog/2010/03/01/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines/#comments Mon, 01 Mar 2010 04:35:25 +0000 drugs http://medsnetic.com/blog/2010/03/01/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines/ In conclusion, Alprazolam, Bromazepam, Chlordiazepoxide, Clonazepam, Diazepam, Lorazepam, Nitrazepam, Oxazepam, Tetrazepam and Triazolam can be considered as safe drugs in term of their inability to induce PXR- and AhR-dependent cytochrome P450 enzymes CYP1A2 and CYP3A4. Medazepam and Midazolam slightly activated pregnane X receptor and displayed weak potency to induce CYP3A4 mRNA in human hepatocytes.
PMI D: 20080160 [PubMed - as supplied by publisher] (Source: Toxicology Letters)

]]> http://medsnetic.com/blog/2010/03/01/benzodiazepines-medazepam-and-midazolam-are-activators-of-pregnane-x-receptor-and-weak-inducers-of-cyp3a4-investigation-in-primary-cultures-of-human-hepatocytes-and-hepatocarcinoma-cell-lines/feed/ 0 Vardenafil Increases Cell Proliferation in the Dentate Gyrus through Enhancement of Serotonin Expression in the Rat Dorsal Raphe. http://medsnetic.com/blog/2010/02/11/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe/ http://medsnetic.com/blog/2010/02/11/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe/#comments Thu, 11 Feb 2010 00:44:52 +0000 drugs http://medsnetic.com/blog/2010/02/11/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe/ This study was conducted to evaluate the effects of vardenafil (Levitra), a phosphodiesterase-5 (PDE-5) inhibitor, on cell proliferation in the hippocampal dentate gyrus and on 5-hyroxytryptamine (5-HT, serotonin) synthesis and tryptophan hydroxylase (TPH) expression in the rat dorsal raphe nucleus. Male Sprague-Dawley rats were divided into 6 groups (n=5 in each group): a control group, a 0.5 mg/kg-1 day vardenafil-treated group, a 1 mg/kg-1 day vardenafil-treated group, a 2 mg/kg-1 day vardenafil-treated group, a 1 mg/kg-3 day vardenafil-treated group, and a 1 mg/kg-7 day vardenafil-treated group. 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry was th en performed to evaluate cell proliferation in the dentate gyru s. In addition, 5-HT and TPH immunohistochemistry was conducted to evalu…

]]> http://medsnetic.com/blog/2010/02/11/vardenafil-increases-cell-proliferation-in-the-dentate-gyrus-through-enhancement-of-serotonin-expression-in-the-rat-dorsal-raphe/feed/ 0 Caffeine augments Alprazolam induced cytotoxicity in human cell lines. http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/ http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/#comments Sat, 06 Feb 2010 12:50:44 +0000 drugs http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/ Auth ors: Saha B, Mukherjee A, Samanta S, Saha P, Ghosh AK, Santra CR, Karmakar P
Combined effects of alprazolam (Alp), a member of benzodiazepine group of drugs and caffeine on human cell lines, HeLa and THP1 were investigated in this study. Alp mediated cytotoxicity was enhanced while caffeine was present. The cell death was confirmed by observing morphological changes, LDH assay and membrane anisotropic study. Also such combined effects induced elevated level of ROS and depletion of GSH. The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associat ed with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3. Our results indicate that, Alp alone induces apoptosis in human…

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]]> http://medsnetic.com/blog/2010/02/06/caffeine-augments-alprazolam-induced-cytotoxicity-in-human-cell-lines/feed/ 0