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Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial

Saturday, May 29th, 2010

AbstractThe respiratory eff ects of benzodiazepines have been controversial. This investigation aimed to study the effe cts of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Ventilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after (more…)

Early onset anxiolytic efficacy after a single dose of pregabalin: double-blind, placebo- and active-comparator controlled evaluation using a dental anxiety model

Wednesday, May 26th, 2010

To evaluate acute onset of anxiolytic activity using a dental anxiety model, 89 patients were randomised to double-blind single dose pregabalin 150 mg, alprazolam 0.5 mg or placebo 4 h before a scheduled dental procedure. A Dental Anxiety Total score >12 (moderate-to-severe) without meeting Diagnostic and Statistical Manual of Mental Di sorders (Fourth edition) (DSM-IV) anxiety disorder criteria was required. Efficacy and safety, assessed (more…)

Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial

Wednesday, February 17th, 2010

AbstractThe respiratory effects of benzodiazepines have been controversial. This investigation aimed to study the effects of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Vent ilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after (more…)

Early onset anxiolytic efficacy after a single dose of pregabalin: double-blind, placebo- and active-comparator controlled evaluation using a dental anxiety model

Sunday, February 14th, 2010

To evaluate acute onset of anxiolytic activity using a dental anxiety model, 89 patients were randomised to double-blind single dose pregabalin 150 mg, alprazolam 0.5 mg or placebo 4 h before a scheduled dental procedure. A Dental Anxiety Total score >12 (moderate-to-severe) without meeting Diagnostic and Statistical Manual of Mental Disorders (Fourth edition) (DSM-IV) anxiety disorder criteria was required. Efficacy and safety, asse ssed (more…)