Findings from a multicenter, double-blind, placebo-controlled study are consistent with previously
reported data showing that tadalafil (Cialis) improves lower urinary tract symptoms associated with BPH. However,
the benefit cannot be explained by effects on pressure-flow urodynamics. (Source: Modern Medicine)
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Ut recht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University (more…)
The use of previous anorectic medications and the combined use of the anorectic medications fenfluramine and phentermine (Fen-Phen) have been associated with varying degrees of valvular regurgitation and pulmonary hypertension. More recent reports have suggested a lower incidence of both than was previously reported. Comparisons of patients with similar body mass index (BMI) hav e been missing as well as information regarding chamber dimensions (more…)
Antiobesity effects of the β-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats
International Journal of Obesity advance online publication, June 17, 2008. doi:10.1038/ijo.2008.91
Au thors: J D Roth, J L Trevaskis, J Wilson, C Lei, J Athanacio, C Mack, N C Kesty, T Coffey, C Weyer
& D G Parkes (Source: International Journal of Obesity)
Conclusion Even though fear-potentiated startle may be used to translate preclini cal evidence to human populations, methodological issues
still hamper the application of this model to early screening of putative anxiolytic drugs.
Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences (more…)
In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of a nxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A receptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which (more…)
Conclusions: These results suggest that although alprazolam did not improve the THI score or sensation level of loudness significantly, it has a desirable effect on VAS. Further work is needed to determine the beneficial effects of alprazolam in distressed or depressed patients. (Source: Medical Science Monitor)
Abstract
Introduction The effects of pre-conditioning administration of anxiolytic benzodiazepines on the acquisition of a conditioned taste aversion
(CTA) and on the acquisition of attenuation of neophobia (AN) were investigated in C57BL/6 mice.
M aterials and methods A CTA was induced by injecting lithium chloride (LiCl; 6 mEq
.
kgâ1) 30 min after the animal had imbibed a novel 0.5% saccharin (more…)
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social S ciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University (more…)
Conclusion: Alprazolam activation of GABA(A) pathways during day 1 hypoglycemia can play an important role in regulating a spectrum of key physiologic responses during subsequent (day 2) hypoglycemia in healthy man.
PMID: 20086227 [PubMed - as supplied by publisher] (Source: Diabetes)
MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly fr om thousands of authoritative (more…)