Online Pharmacy US » experimental http://medsnetic.com/blog Viagra, Xanax, Cialis, Phentermine, Levitra Fri, 10 Sep 2010 21:39:18 +0000 http://wordpress.org/?v=2.9.2 en hourly 1 Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma. http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/ http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/#comments Tue, 25 May 2010 13:56:58 +0000 drugs http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/ Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase extraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design was used with extraction time, temperature and solvent volume as influential parameters. A desirability function was employed in addition to the simultaneous optimization of the MAE condition s. The analysis of variance showed that the solvent volume had a positive influence on the extraction of all the analytes tested, achieving a statistically sig…

]]> http://medsnetic.com/blog/2010/05/25/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma-2/feed/ 0 A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/ http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/#comments Fri, 21 May 2010 14:51:22 +0000 drugs http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/ In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of a nxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A receptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which are now in early phase clinical studies and are showing selective efficacy in pharmacodynamic studies. (Source: Journal of Psychopharmacology)

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]]> http://medsnetic.com/blog/2010/05/21/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety-2/feed/ 0 Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma. http://medsnetic.com/blog/2010/03/08/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma/ http://medsnetic.com/blog/2010/03/08/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma/#comments Mon, 08 Mar 2010 07:18:20 +0000 drugs http://medsnetic.com/blog/2010/03/08/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma/ Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase e xtraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design was used with extraction time, temperature and solvent volume as influential parameters. A desirability function was employed in addition to the simultaneous optimization of the MAE conditions. The analysis of variance showed that the solvent volume had a positive influence on the extraction of all the analytes tested, achieving a statistically sig…

]]> http://medsnetic.com/blog/2010/03/08/experimental-design-for-optimization-of-microwave-assisted-extraction-of-benzodiazepines-in-human-plasma/feed/ 0 A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/ http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/#comments Tue, 16 Feb 2010 08:55:34 +0000 drugs http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/ In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of anxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A rec eptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which are now in early phase clinical studies and are showing selective efficacy in pharmacodynamic studies. (Source: Journal of Psychopharmacology)

]]> http://medsnetic.com/blog/2010/02/16/a-comparison-of-the-effects-of-a-subtype-selective-and-non-selective-benzodiazepine-receptor-agonist-in-two-co2-models-of-experimental-human-anxiety/feed/ 0