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Authors: Saha B, Mukherjee A, Samanta S, Saha P, Ghosh AK, Santra CR, Karmakar P
Combined effects of alprazolam (Alp), a member of benzodiazepine group of drugs and caffeine on human cell lines, HeLa and THP1 were investigated in this stu dy. Alp mediated cytotoxicity was enhanced while caffeine was present. The cell death was confirmed by observing morphological changes, LDH assay and membrane anisotropic study. Also such combined effects (more…)

Conclusions  At sufficiently high doses, flunitrazepam can engender increases in risky decision making. Globally, these changes appear
similar to previous effects we have observed after acute administration of alcohol and alprazolam. As suggested by the EVM
outcomes, the mechanisms underlying the changes in risky decision making are more similar to alprazolam than alcohol.

Content Type Journal ArticleCategory Original InvestigationDOI (more…)

Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Ut recht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University (more…)

A joke among two Texas AgriLife Research scientists later turned into a fully-funded study. Viagra can aid fetal development in female sheep. Female sheep (ewes) are an agriculturally important species, which can se rve as an excellent animal model for studying the physiology of human pregnancy, the researchers said… (Source: Biology / Biochemistry News From Medical News Today)

Authors: Lake ST, Altman PM, Vaisman J, Addison RS
A sensitive high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) assay has been developed for the quantitative analysis of vardenafil in human plasma. Vardenafil and the internal standard, alprazolam, were extracted from 0.2 mL aliquots of alkalinized plasma by a single solvent extractio n into hexane : dichloromethane. Reversed-phase chromatographic separation was (more…)

Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase extraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design (more…)

A joke among two Texas AgriLife Research scientists later turned into a fully-funded study. Viagra can aid fetal development in female sheep. Female sheep (ewes) are an agriculturally important species, which can serve as an excellent animal model for studying the physiology of human pregnancy, the researchers said. Viagr a (sildenafil citrate), which is used to treat male erectile dysfunction, enhanced blood flow in pregnant female sheep, helping (more…)

Conclusion  Even though fear-potentiated startle may be used to translate preclini cal evidence to human populations, methodological issues
still hamper the application of this model to early screening of putative anxiolytic drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences (more…)

Authors: Nakamura M, Ohmori T, Itoh Y, Terashita M, Hirano K
A liquid chromatography-tandem ma ss spectrometry (LC-MS/MS) method using a high-resolution octa decyl silica column compatible with aqueous compounds was developed for the simultaneous determination of benzodiazepines and their metabolites in human serum. This method enabled us to determine multiple benzodiazepines, including flurazepam, bromazepam, chlordiazepoxide, nitrazepam, (more…)

In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of a nxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A receptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which (more…)