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In conclusion, Alprazolam, Bromazepam, Chlordiazepoxide, Clonazepam, Di azepam, Lorazepam, Nitrazepam, Oxazepam, Tetrazepam and Triazolam can be considered as safe drugs in term of their inability to induce PXR- and AhR-dependent cytochrome P450 enzymes CYP1A2 and CYP3A4. Medazepam and Midazolam slightly activated pregnane X receptor and displayed weak potency to induce CYP3A4 mRNA in human hepatocytes.
PMID: 20080160 [PubMed – as supplied (more…)

Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-010-1837-4Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social S ciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University (more…)

Authors: Fernández P, Vázquez C, Lorenzo RA, Carro AM, Alvarez I, Cabarcos P
A simple and fast microwave-assisted-extraction (MAE) method has been evaluated as an alternative to solid-phase e xtraction (SPE) for the determination of six benzodiazepines widely prescribed in European countries (alprazolam, bromazepam, diazepam, lorazepam, lormetazepam and tetrazepam) in human plasma. For MAE optimization a Doehlert experimental design (more…)

A joke among two Texas AgriLife Research scientists later turned into a fully-funded study. Viagra can aid fetal development in female sheep. Female sheep (ewes) are an agriculturally important species, which can serve as an excellent animal model for studying the physiology of human pregnancy, the researchers said… (Source: Biology / Biochemistry News From Medical N ews Today)

In conclusion, Alprazolam, Bromazepam, Chlordiazepoxide, Clonazepam, Diazepam, Lorazepam, Nitrazepam, Oxazepam, Tetrazepam and Triazolam can be considered as safe drugs in term of their inability to induce PXR- and AhR-dependent cytochrome P450 enzymes CYP1A2 and CYP3A4. Medazepam and Midazolam slightly activated pregnane X receptor and displayed weak potency to induce CYP3A4 mRNA in human hepatocytes.
PMI D: 20080160 [PubMed – as supplied (more…)

Conclusion  Even though fear-potentiated startle may be used to translate preclinical evidence to human populations, methodological issues
still hamper the application of this model to early screening of putative anxiolytic drugs.

Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors
J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences (more…)

In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of anxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A rec eptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which (more…)

Authors: Lake ST, Altman PM, Vaisman J, Addison RS
A sensitive high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) assay has been developed for the quantitative analysis of vardenafil in hum an plasma. Vardenafil and the internal standard, alprazolam, were extracted from 0.2 mL aliquots of alkalinized plasma by a single solvent extraction into hexane : dichloromethane. Reversed-phase chromatographic separation was (more…)

C onclusions  At sufficiently high do ses, flunitrazepam can engender increases in risky decision making. Globally, these changes appear
similar to previous effects we have observed after acute administration of alcohol and alprazolam. As suggested by the EVM
outcomes, the mechanisms underlying the changes in risky decision making are more similar to alprazolam than alcohol.

Content Type Journal ArticleCategory Original InvestigationDOI (more…)

To the Editor: The article titled Sildenafil citrate (Viagra) impairs fertilization and early embryo development in mice by Glenn et al. was of great interest. However, the presented data should be clarified from a teratological point of view, as it is insufficient for any further toxicological evaluation, in particular the human risk assessment. Without recording the initial number of females selected to each examined group, it is impossible (more…)