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AbstractThe respiratory eff ects of benzodiazepines have been controversial. This investigation aimed to study the effe cts of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Ventilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after (more…)

PHILADELPHIA – The diet drug special master on Dec. 31 recommended against allowing a plaintiff to assert primary pulmonary hypertension (PPH) at trial in the Philadelphia Court of Common Pleas, saying it is a settled claim because the plaintiff failed to rule out primary cardiac disease as a cause of her elevated pulmonary arterial pressure (In Re: Diet Drugs [Phentermine/Fenfluramine/Dexfenfluramine] Products Liability Litigation, MDL Docket (more…)

Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA) announced that it has completed the enrollment in its Phase 2a proof-of-concept clinical trial with AZ-002 (Staccato(R) alprazolam) in patients with panic disorder. AZ-002 is an inhalation product candidate being developed for the acute treatment of panic attacks associated with panic disorder. AZ-002 is being developed through Symphony Allegro, a development collaboration formed between Alexza and (more…)

AlexzaPharmaceuticals, Inc. ( Nasdaq: ALXA) announced today that it has initiateda Phase IIa clinical trial with AZ-002 (Staccato(TM) alprazolam) inpatients with panic disorder. AZ-002 is an inhalation product candidatebeing developed for the acute treatment of panic attacks associated withpanic disorder. The Phase IIa clinical trial is an in-clinic proof of concept study. [click link for full article] (Source: Mental Health News From Medical (more…)

Authors: Aronne LJ, Halseth AE, Burns CM, Miller S, Shen LZ
Preclinical evidence suggests that pharmacotherapy for obesity using combinations of agents targeted at distinct regulatory pathways may produce robust additive or synergistic effects on weight loss. This randomized placebo-controlled trial examined the safety and efficacy of the amylin analogue pramlintide alone or in combination with either phentermine or sibutramine. All patients (more…)

Conclusions: These results suggest that although alprazolam did not improve the THI score or sensation level of loudness significantly, it has a desirable effect on VAS. Further work is needed to determine the beneficial effects of alprazolam in distressed or depressed patients. (Source: Medical Science Monitor)

Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Lungs General)

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Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet High Blood Pressure General)

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Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Cancer General)

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The National Institutes of Health has stopped a trial of Viagra that was intended to see whether the drug could be used to treat pulmonary hypertension in patients with sickle cell disease. (Source: NYT > Health)

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