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Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial

drugs — Sat, 29 May 2010 10:55:15 +0000

AbstractThe respiratory eff ects of benzodiazepines have been controversial. This investigation aimed to study the effe cts of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Ventilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after drug intake. Subjects were encouraged to keep their eyes open. Mean ± SD minute ventilation 120 min after alprazolam and placebo was similar (6.21 ± 0.71 vs 6.41 ± 1.12 L/min, P = NS). End-tidal PCO2 and oxygen saturation did also not differ between treatments. However, coefficients…

Special Master Recommends PPH Plaintiff Not Be Allowed To Pursue Claims At Trial

drugs — Fri, 28 May 2010 03:34:24 +0000

PHILADELPHIA – The diet drug special master on Dec. 31 recommended against allowing a plaintiff to assert primary pulmonary hypertension (PPH) at trial in the Philadelphia Court of Common Pleas, saying it is a settled claim because the plaintiff failed to rule out primary cardiac disease as a cause of her elevated pulmonary arterial pressure (In Re: Diet Drugs [Phentermine/Fenfluramine/Dexfenfluramine] Products Liability Litigation, MDL Docket No. 120 3, Sheila Brown, et al. v. American Home Products Corp., No. 99-20593, E.D. Pa., Nancy Cochran v. Wyeth, et al., No. 0002 75, Pa. Comm. Pls., Phila. Co.; See December 2007, Page 13).
Full story on lexis.com (Source: LexisNexis® Mealey’s™ Fen-Phen/Redux Legal News)

Alexza Completes Enrollment In Phase 2a Clinical Trial With AZ-002 (Staccato(R) Alprazolam) In Panic Disorder Patients

drugs — Fri, 28 May 2010 01:56:34 +0000

Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA) announced that it has completed the enrollment in its Phase 2a proof-of-concept clinical trial with AZ-002 (Staccato(R) alprazolam) in patients with panic disorder. AZ-002 is an inhalation product candidate being developed for the acute treatment of panic attacks associated with panic disorder. AZ-002 is being developed through Symphony Allegro, a development collaboration formed between Alexza and S ymphony Capital in 2006. (Source: Psychology / Psychiatry News From Medical News Today)

Alexza Initiates AZ-002 Phase IIa Clinical Trial In Patients With Panic Disorder

drugs — Mon, 24 May 2010 19:06:07 +0000

AlexzaPharmaceuticals, Inc. ( Nasdaq: ALXA) announced today that it has initiateda Phase IIa clinical trial with AZ-002 (Staccato(TM) alprazolam) inpatients with panic disorder. AZ-002 is an inhalation product candidatebeing developed for the acute treatment of panic attacks associated withpanic disorder. The Phase IIa clinical trial is an in-clinic proof of concept study. [click link for full article] (Source: Mental Health News From Medical News Today)

Enhanced Weight Loss Following Coadministration of Pramlintide With Sibutramine or Phentermine in a Multicenter Trial.

drugs — Thu, 20 May 2010 21:56:10 +0000

Authors: Aronne LJ, Halseth AE, Burns CM, Miller S, Shen LZ
Preclinical evidence suggests that pharmacotherapy for obesity using combinations of agents targeted at distinct regulatory pathways may produce robust additive or synergistic effects on weight loss. This randomized placebo-controlled trial examined the safety and efficacy of the amylin analogue pramlintide alone or in combination with either phentermine or sibutramine. All patients also received lifestyle intervention. F ollowing a 1-we ek placebo lead-in, 244 obese or overweight, nondiabetic subjects (88% female; 41 +/- 11 years; BMI 37.7 +/- 5.4 kg/m(2); weight 103 +/- 19 kg; mean +/- s.d.) received placebo subcutaneously (sc) t.i.d., pramlintide sc (120 microg t.i.d.), pramlintide sc (120 microg t.i.d.) + oral sibutramine (1…

Med Sci Monit 2009; 15(11):PI55-60 "The effects of alprazolam on tinnitus: A cross-over randomized clinical trial"

drugs — Wed, 19 May 2010 20:39:19 +0000

Conclusions: These results suggest that although alprazolam did not improve the THI score or sensation level of loudness significantly, it has a desirable effect on VAS. Further work is needed to determine the beneficial effects of alprazolam in distressed or depressed patients. (Source: Medical Science Monitor)

Viagra Trial for Sickle Cell Lung Problems Halted

drugs — Tue, 20 Apr 2010 09:01:58 +0000

Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Lungs General)

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Viagra Trial for Sickle Cell Lung Problems Halted

drugs — Fri, 02 Apr 2010 14:10:31 +0000

Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet High Blood Pressure General)

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Viagra Trial for Sickle Cell Lung Problems Halted

drugs — Sat, 13 Mar 2010 05:35:29 +0000

Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Cancer General)

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National Briefing | Science and Health: Viagra Trial Is Halted

drugs — Fri, 12 Mar 2010 21:52:48 +0000

The National Institutes of Health has stopped a trial of Viagra that was intended to see whether the drug could be used to treat pulmonary hypertension in patients with sickle cell disease. (Source: NYT > Health)

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Viagra Trial for Sickle Cell Lung Problems Halted

drugs — Sat, 06 Mar 2010 13:42:11 +0000

Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/29/2009 (Source: MedicineNet Senior Health Genera l)

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Alexza Announces Preliminary Results From its AZ-002 (Staccato Alprazolam) Phase 2a Proof-of-Concept Trial in Patients With Panic Disorder

drugs — Thu, 04 Mar 2010 16:13:12 +0000

MOUNTAIN VIEW, Calif., June 09, 2008 /PRNewswire-FirstCall/ –
Alexza Pharmaceuticals, Inc. announced today preliminary results
from its Phase 2a proof-of-concept clinical trial with AZ-002
(Staccato(R) alprazolam) in patients with panic disorder…. (Source: Drugs.com – Clinical Tr ials)

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Viagra Trial for Sickle Cell Lung Problems Halted

drugs — Wed, 03 Mar 2010 06:46:42 +0000

Title: Viagra Trial for Sickle Cell Lung Problems HaltedCategory: Health NewsCreated: 7/29/2009 7:00:00 AMLast Editorial Review: 7/ 29/2009 (Source: MedicineNet Mens Health General)

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Med Sci Monit 2009; 15(11):PI55-60 "The effects of alprazolam on tinnitus: A cross-over randomized clinical trial"

drugs — Wed, 03 Mar 2010 04:51:48 +0000

Gene therapy for erectile dysfunction shows promise in clinical trial

drugs — Wed, 03 Mar 2010 00:11:46 +0000

The first human trial of gene transfer therapy for erectile dysfunction (ED) indicates that gene therapy that lasts for month s and eliminates the patient’s need for on-demand drugs (such as Viagra and Cialis), could become the future treatment of choice for this common problem, according to a paper in the most recent issue of Human Gene Therapy. (Source: EurekAlert! – Biology)

Alexza Initiates AZ-002 Phase IIa Clinical Trial In Patients With Panic Disorder

drugs — Mon, 01 Mar 2010 15:42:22 +0000

AlexzaPharmaceuticals, Inc. (Nasdaq: ALXA) announced today that it has initiateda Phase IIa clinical trial with AZ-002 (Staccato(TM) alprazolam) inpatients with panic disorder. AZ-002 is an inhalation product candidatebeing developed for the acute treatment of panic attacks associated withpanic disorder. The Phase IIa clinical trial is an in-clinic proof of concept study. [click link for full article] (Source: Mental Health News From Medica l News Today)

Gene Therapy For Erectile Dysfunction Shows Promise In Clinical Trial

drugs — Sun, 28 Feb 2010 21:27:46 +0000

The first human trial of gene transfer therapy for erectile dysfunction (ED) indicates that gene therapy that lasts for months and eliminates the patient’s need for on-demand drugs (such as Viagra and Cialis), could become the future treatment of choice for this common problem, according to a paper in the most recent issue of Human Gene Therapy. [click link for full article] (Source: Health News from Medic al News Today)

Gene Therapy For Erectile Dysfunction Shows Promise In Clinical Trial

drugs — Sun, 21 Feb 2010 23:36:47 +0000

The first human trial of gene transfer therapy for erectile dysfunction (ED) indicates that gene therapy that lasts for months and eliminates the patient’s need for on-demand drugs (such as Viagra and Cialis), could become the future t reatment of choice for this common problem, according to a paper in the most recent issue of Human Gene Therapy. [click link for full article] (Source: Genetics News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and new s sources.

Enhanced Weight Loss Following Coadministration of Pramlintide With Sibutramine or Phentermine in a Multicenter Trial.

drugs — Thu, 18 Feb 2010 09:06:04 +0000

Authors: Aronne LJ, Halseth AE, Burns CM, Miller S, Shen LZ
Preclinical evidence suggests that pharmacotherapy for obesi ty using combinations of agents targeted at distinct regulatory pathways may produce robust additive or synergistic effects on weight loss. This randomized placebo-controlled trial examined the safety and efficacy of the amylin analogue pramlintide alone or in combination with either phentermine or sibutramine. All patients also received lifestyle intervention. Following a 1-week placebo lead-in, 244 obese or overweight, nondiabetic subjects (88% female; 41 +/- 11 years; BMI 37.7 +/- 5.4 kg/m(2); weight 103 +/- 19 kg; mean +/- s.d.) received placebo subcutaneously (sc) t.i.d., pramlintide sc (120 microg t.i.d.), pramlintide sc (12 0 microg t.i.d.) + oral sibutramine (1…

Special Master Recommends PPH Plaintiff Not Be Allowed To Pursue Claims At Trial

drugs — Thu, 18 Feb 2010 02:43:28 +0000

PHILADELPHIA – The diet drug special master on Dec. 31 recommended against allowing a plaintiff to assert primary pulmonary hypertension (PPH) at trial in the Philadelphia Court of Common Pleas, saying it is a settled claim because the plaintiff failed to rule out primary cardiac disease as a cause of her elevated pulmonary arterial pressure (In Re: Diet Drugs [Phentermine/Fenfluramine/Dexfenfluramine] Produ cts Liability Litigation, MDL Docket No. 1203, Sheila Brown, et al. v. American Home Products Cor p., No. 99-20593, E.D. Pa., Nancy Cochran v. Wyeth, et al., No. 000275, Pa. Comm. Pls., Phila. Co.; See December 2007, Page 13).
Full story on lexis.com (Source: LexisNexis® Mealey’s™ Fen-Phen/Redux Legal News)

Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial

drugs — Wed, 17 Feb 2010 07:06:37 +0000

AbstractThe respiratory effects of benzodiazepines have been controversial. This investigation aimed to study the effects of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Vent ilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after drug intake. Subjects were encouraged to keep their eyes open. Mean ± SD minute ventilation 120 min after alprazolam and placebo was similar (6.21 ± 0.71 vs 6.41 ± 1.12 L/min, P = NS). En d-tidal PCO2 and oxygen saturation did also not differ between treatments. However, coefficients…